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Actin binding proteins and transcription factors are essential in regulating plant root hair growth in response to various environmental stresses;however, the interaction between these two factors in ...
经典的细胞骨架是由微管(microtubule)、微丝(F-actin)或者中间丝组成的三维网络结构,在细胞的稳定性维持、胞内物质运输以及细胞运动方面发挥关键作用。除此之外,动物细胞中还存在一种以血影蛋白spectrin为基础的二维网状形式的膜骨架系统。膜骨架平行于细胞膜分布,紧贴在细胞膜内侧,赋予细胞膜更高的机械强度和可塑性(Lux, 2016)(图1)。膜骨架与细胞膜的功能活动密切关联:通过与...
近日,中国科学技术大学教授许超课题组与波兰华沙大学Jakub Drozak实验室合作,解析了SETD3与β-actin多肽的高分辨复合物晶体结构,并结合酶活实验揭示了肌动蛋白(Actin)第73位组氨酸(His73)的N3位甲基化的作用机制,相关成果于2月20日以Structural insights into SETD3-mediated histidine methylation on β-a...
近日,中国科学技术大学许超教授课题组与波兰华沙大学Jakub Drozak实验室合作,解析了SETD3与β-actin多肽的高分辨复合物晶体结构,并结合酶活实验揭示了肌动蛋白(Actin)第73位组氨酸(His73)的N3位甲基化的作用机制,相关成果以“Structural insights into SETD3-mediated histidine methylation on β-actin”...
近日,中国科学技术大学许超教授课题组与波兰华沙大学Jakub Drozak实验室合作,解析了SETD3与β-actin多肽的高分辨复合物晶体结构,并结合酶活实验揭示了肌动蛋白(Actin)第73位组氨酸(His73)的N3位甲基化的作用机制,相关成果以“Structural insights into SETD3-mediated histidine methylation on β-actin”...
病原入侵宿主细胞,由宿主细胞肌动蛋白(F-actin)聚集引起的细胞骨架重排起着极其重要的作用,本文主要就宿主细胞整合素介导的宿主细胞F-actin聚集重排在顶复门原虫入侵过程中的作用进行系统的阐述,对解析顶复门原虫的入侵机制及以此研制新型寄生虫病药物和疫苗具有非常重要的意义。
In response to glucose, pancreatic islet beta cells secrete insulin in a biphasic manner, and both phases are diminished in type 2 diabetes. In beta cells, cortical F-actin beneath the plasma membrane...
The contractile activation of airway smooth muscle tissues stimulates actin polymerization and the inhibition of actin polymerization inhibits tension development. Actin depolymerizing factor (ADF) an...
ANALYSIS OF AN ACTIN BINDING GUANINE EXCHANGE FACTOR, GEF8, AND ACTIN DEPOLYMERIZING FACTOR IN ARABIDOPSIS THALIANA. April, 2010 Aleksey Chudnovskiy, B.S., UNIVERSITY OF MASSACHUSETTS AMHERST M.S., UN...
The generation of site-directed mutants within the actin binding domain of the EGF receptor modulates receptor function in internalization and ligand binding. In addition, truncation of the EGFr at re...
Pollen tube growth, the process that transports the sperm cell to the ovule, is fundamental for plant sexual reproduction. The actin cytoskeleton is essential to the process of pollen tube elongation....
It has been shown that the epidermal growth factor receptor (EGFR) can directly interact with F-actin via an actin-binding domain (ABD) located at amino acid residues 984–996. In this study, we invest...
Cell adhesion to an extracellular matrix plays a critical role in many aspects of normal cell function. Cells display various modes of interaction with the extracellular matrix; they may attach and sp...
Cytokinesis, the process of physically separating cells for division, requires the precise orchestration of numerous physical, mechanical, chemical and biological processes. For these processes to fun...
At the adult frog neuromuscular junctions (Rana pipien and Rana catesbiana), F-actin microfilaments are enriched in the nonrelease domains of nerve terminals, outside the vesicle-rich release sites. T...

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