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中国科学院武汉病毒研究所揭示新型CRISPR-Cas系统的分子机制（图）
免疫,基因,病毒
2024/8/19
2024年8月19日，中国科学院武汉病毒研究所邓增钦团队与天津医科大学基础医学院张恒团队合作，在《自然》（Nature）上发表了题为Structural basis for the activity of the type VII CRISPR-Cas system的研究论文。该研究证实了VII型CRISPR-Cas系统能够特异性识别细胞内转录本并靶向敲低基因表达，并能够帮助宿主菌抵抗噬菌体的感染...
中国科学院动物研究所专利：工程化的Cas效应蛋白及其使用方法
中国科学院动物研究所 专利 工程化 Cas效应蛋白
2024/5/30
本文提供了用于工程化改造酶诸如Cas核酸酶以增加其酶活性的方法。还提供了工程化的Cas效应蛋白，包括工程化的Cas12b、Cas12i和Cas9核酸酶及其衍生物，以及其使用方法。
由CRISPR-Cas系统引起的基因组编辑革命浪潮中，CRISPR-Cas9系统及其衍生的精准编辑工具（包括碱基编辑和引导编辑）因其简单高效的特点，极大地加速了作物遗传育种的进程。基因组编辑工具在作物基因组工程上的应用通常依赖于农杆菌介导的遗传转化，该过程受到作物品种以及植物组织培养条件的诸多限制。因此通过植物病毒载体递送基因组编辑工具，绕过组织培养直接获得基因组编辑过的植株受到越来越多的关注。由...
耦合模式对于年平均赤道太平洋海表温度的模拟有着很大的偏差，主要体现在赤道中太平洋和西太平洋的冷偏差以及赤道东太平洋的暖偏差。尽管随着模式的发展，赤道太平洋海表温度的模拟有了一定改进，CMIP6模式集合平均历史实验（HIST）的结果表明偏差依旧显著存在。 CAS-ESM2-0作为参与了CMIP6的耦合模式，其历史实验（HIST）结果在赤道太平洋海表温度的模拟偏差和CMIP6模式集合平均的模拟偏差类似...
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars：基于stPCA降维算法的ICU病人出院策略法
stPCA降维算法 ICU病人 出院策略法
2023/12/11
许多复杂生物系统可以由高维非线性动力系统描述，对原始数据进行降维有助于对这些系统进行有效分析。然而以一种可解释的方式进行极致低尺度的降维仍然是一个具有挑战性的问题。基于Takens延迟嵌入理论，将高维空间信息转换为低维时间信息，我们开发了极致低降维算法stPCA，并将其应用于重症监护医疗信息管理系统MIMIC-III和MIMIC-IV数据集，提出了ICU病人的出院决策。stPCA基于ICU患者的高...
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars：The Development of Science: Past and Present What about the future? A publisher’s point of view
出版史 传播 人工智能
2023/12/11
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars：The Development of Science: Past and Present What about the future? A publisher’s point of view.
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars：Global large strong solutions to the 2D radially symmetric compressible Navier-Stokes equations on bounded domain
有界域 二维径向对称 可压缩Navier-Stokes方程 全局大强解
2023/12/11
In this talk, I will present our recent result the 2D radially symmetric compressible Navier-Stokes equations with density-dependent viscosity. Under the condition of beta>1, we prove the global exist...
Nonhomologous end joining as key to CRISPR/Cas-mediated plant chromosome engineering
CRISPR Cas plant chromosome；plant breeding；Arabidopsis thaliana；Genome editing NHEJ
2023/11/30
Although clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas)-mediated gene editing has revolutionized biology and plant breeding, large-scale, heritable ...
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars：Well-balanced positivity-preserving high-order discontinuous Galerkin methods for Euler equations with gravitation
引力 欧拉方程 高阶间断 Galerkin方法
2023/11/29
We develop high order discontinuous Galerkin (DG) methods with Lax-Friedrich fluxes for Euler equations under gravitational fields. Such problems may yield steady-state solutions and the density and p...
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars：Occupation fields for Markov loops
马尔可夫循环 占用域 格林函数
2023/11/29
In this talk, we introduce occupation fields for vertices and oriented edges and compute their distributions. More precisely, under the Markov loop measure, the expected number for crossings of an ori...
Covering the Combinatorial Design Space of Multiplex CRISPR/Cas Experiments in Plants
combinatorial gene knockout libraries crop breeding experimental design multiplex CRISPR/Cas screens plant genetic studies
2023/11/28
Over the past years, CRISPR/Cas-mediated genome editing has revolutionized plant genetic studies and crop breeding. Specifically, due to its ability to simultaneously target multiple genes, the multip...
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars：Nonlinear potentials at the fractional scale:sharp regularity
分数尺度 非线性势 尖锐 正则性
2023/11/29
Nonlinear potential theory and elliptic regularity theory are two classical topics in the modern analysis of partial differential equations. In this talk I show how these themes merge to solve the lon...
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars：Adaptive stabilization of non-cooperative stochastic differential games
非合作 随机微分对策 自适应镇定
2023/11/29
We considers the adaptive stabilization problem for a basic class of linear-quadratic non-cooperative stochastic differential games when the systems matrices are unknown to the regulator and the playe...
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars：Distributed sparse identification theory and method
分布式 稀疏识别 理论方法
2023/11/29
In this talk, we will consider the distributed sparse identification problem over wireless sensor networks such that all sensors cooperatively estimate the unknown sparse parameter vector of stochasti...
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars："Sobolev extensions"(7)&(8)
Sobolev扩展 Whitney扩展 技术变体
2023/11/29
I will give an introduction to Sobolev extensions, including the use of variants of the Whitney extension technique. I will concentrate on the basics of the theory.