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心血管疾病是全球死亡的主要原因，多域性动脉粥样硬化与较高的心血管疾病风险有关。研究表明，亚临床颈动脉粥样硬化和冠状动脉钙化增加血管事件的风险。此外，亚洲人群中颅内动脉粥样硬化患病率可能较白人高，约有三分之一的老年社区人群患有颅内动脉粥样硬化，导致缺血性卒中发生率更高。因此，需要对多域性动脉粥样硬化病变进行综合评价，以充分了解动脉粥样硬化的分布和负担，准确评估未来心脑血管事件的风险。然而，关于社区人...
P53 “master switch” remains top target in gene signaling network controlling cancer suppression（图）
P53 master switch top target gene signaling network controlling cancer suppression
2017/10/25
There are two important categories of genes involved in cancer development, oncogenes and tumor suppressor genes. When oncogenes gain function, e.g. through mutation, they actively promote cancer – dr...
Penn Engineers Use Network Science to Predict How Ligaments Fail
Penn Engineers Network Science Ligaments Fail
2016/2/23
When doctors diagnose a torn ligament, it’s usually because they can see ruptures in the ligament’s collagen fibers, visible on a variety of different scans. However, they also often treat patients wi...
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α
thymic epithelial microRNA network elevates threshold infection-associated
2012/2/1
Thymic output is a dynamic process, with high activity at birth punctuated by transient periods of involution during infection. Interferon-α (IFN-α) is a critical molecular mediator of pathogen-induce...
International network receives $20m to combat malaria drug resistance（图）
International network $20m malaria drug resistance antimalarial drug
2009/6/15
An international network of malaria scientists is to be established to map the emergence of resistance to antimalarial drugs and guide global efforts to control and eradicate the disease, thanks to a ...