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Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
Structure Mpro SARS-CoV-2 discovery inhibitors
2020/6/12
A new coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the aetiological agent responsible for the 2019–2020 viral pneumonia outbreak of coronavirus disease 2019 (...
CIS REGULATORY MODULE DISCOVERY IN TH1 CELL DEVELOPMENT
TH1 cell development STAT4 ChIP-on-chip ChIP-Seq
2015/5/26
Immune response enables the body to resist foreign invasions. The Inflammatory response is an important aspect in the immune response which is articulated by elements such as cytokines, APC, T-cell an...
Biomarker Discovery in Early Stage Breast Cancer Using Proteomics Technologies
Biomarker Proteomics
2015/5/26
Among women in the United State, breast cancer is the most common cancer
diagnosed in women with approximately 200,000 new cases reported each year and the
second leading cause of cancer-related dea...
Discovery of novel regulators of aldehyde dehydrogenase isoenzymes
ALDH2 Characterization High-throughput docking approach
2015/5/25
Recent work has shown that specific ALDH isoenzymes can contribute to the underlying pathology of different diseases. Many ALDH isozymes are important in oxidizing reactive aldehydes resulting from li...
Variable selection and structural discovery in joint models of longitudinal and survival data
Joint models Mixed effect selection Structural discovery Adaptive LASSO Gaussian quadrature EM algorithm
2015/5/21
Joint models of longitudinal and survival outcomes have been used with increasing frequency in clinical investigations. Correct specification of fixed and random effects, as well as their functional f...
TOWARDS DISCOVERY OF NOVEL TUMOUR MARKERS FOR HEAD AND NECK CANCERS
NECK CANCERS NOVEL TUMOUR MARKERS
2015/3/20
Recent advances in genomic technology, in particular gene expression profiling, may elucidate novel tumour markers
or signatures that will predict how various tumours will behave and respond to vario...
Simulated Drug Discovery Process to Conduct a Synoptic Assessment of Pharmacy Students
synoptic assessment drug discovery integrated learning simulation
2018/7/3
Objective. To implement and assess a task-based learning exercise that prompts pharmacy students to integrate their understanding of different disciplines.
Design. Master of pharmacy (MPharm degree) ...
《Transporters in Drug Development: Discovery, Optimization, Clinical Study and Regulation》（图）
Transporters in Drug Development: Discovery, Optimization, Clinical Study and Regulation Yuichi Sugiyama Bente Steffansen
2013/12/4
With chapters written by leading researchers in the transporter field from academia, pharmaceutical industry, and regulatory agencies, this volume advises on how membrane transporters can be dealt wit...
Alois Alzheimer: a hundred years after the discovery of the eponymous disorder
Alois Alzheimer hundred years discovery eponymous disorder
2009/4/20
The familiar term "Alzheimer's disease" was coined by Emil Kraepelin to honour his pupil, Alois Alzheimer. However, little is known about the life of the man after whom this important and well-kn...
《Optimizing the Drug-Like Properties of Leads in Drug Discovery》（图）
Optimizing the Drug-Like Properties of Leads in Drug Discovery Ronald T. Borchardt Edward H. Kerns Michael Hageman Dhiren R. Thakker James L. Stevens
2013/12/4
This title is the fourth volume of the AAPS series, Biotechnology: Pharmaceutical Aspects. Based on workshops organized by the American Association of Pharmaceutical Scientists in 2003 and 2004, Optim...
DISCOVERY OF TWO MORE NEW SPECIES OF SIMULIUM (MONTISIMULIUM) (DIPTERA: SIMULIIDAE) IN DOI INTHANON NATIONAL PARK, CHIANG MAI, THAILAND
black fly Simuliidae Simulium
2010/12/10
Two more new black-fly species of the rare subgenus Simulium (Montisimulium) were discovered in Doi Inthanon National Park, Chiang Mai, Thailand, where S. (M.) merga Takaoka and Choochote was known as...
《Pharmaceutical Profiling in Drug Discovery for Lead Selection》（图）
Pharmaceutical Profiling in Drug Discovery for Lead Selection Ronald T. Borchardt Edward H. Kerns Christopher A. Lipinski Dhiren R. Thakker Binghe Wang
2013/12/4
Volume 1 of the AAPS Press series, Biotechnology: Pharmaceutical Aspects. Based on a 2003 AAPS workshop of the same name, Pharmaceutical Profiling in Drug Discovery for Lead Selection emphasizes the i...