搜索结果: 1-14 共查到“知识库 生物化学 Cell”相关记录14条 . 查询时间(0.048 秒)
基因表达的精准调控，对机体发育和细胞的各种生理功能的维持至关重要。真核生物基因的转录主要分为转录起始（initiation）、暂停-释放（pausing-release）、延伸（elongation）和终止（termination）四个步骤，转录进程的顺利进行与DNA修饰、组蛋白修饰和RNA修饰等表观遗传修饰高度相关【1】。组蛋白修饰（histone modification）是指组蛋白在相关酶催...
Annual Review of Cell and Developmental Biology丨杨力研究员受邀合作发表环形RNA长篇年鉴综述（图）
杨力研究员 生物医学研究院 生物化学
2023/4/14
2022年10月，复旦大学生物医学研究院杨力研究员受邀与国际同行在Annual Review of Cell and Developmental Biology期刊正式发表了题为“Biogenesis and Regulatory Roles of Circular RNAs”的长篇年鉴综述论文。该论文从同类型环形RNA的研究历程入手，将众多同类型的环形RNA依据其生成加工机制进行了系统分类，并针...
浙江大学生命科学研究院2022年3月28日朱永群实验室在Cell Host & Microbe合作发文揭示新冠VOCs的单克隆抗体35B5中和Omicron的作用机制（图）
朱永群 单克隆抗体 毒株奥密克戎 蛋白 突变
2022/10/25
自去年11月份被发现以来，SARS-CoV-2 超级毒株奥密克戎（Omicron）迅速在全球传播并逐步取代了先前的受关注突变体（Variants of Concern, VOCs），该毒株在Spike蛋白中有30多个突变，使其能够逃避多数治疗性中和抗体以及一些疫苗的免疫疫。因此，开发针对Omicron的强效中和抗体，具有重要临床意义。
2022年3月23 日，Molecular Cell在线发表了云南大学生物医药研究院陈大华团队完成的关于AGO蛋白调控新生多肽泛素化的最新研究论文。该研究详细阐述了AGO蛋白在内质网上发生相分离并且招募E3泛素连接酶Ltn1来参与新生多肽泛素化的调控。
E-Cadherin Tethered to Micropatterned Supported Lipid Bilayers as a Model for Cell Adhesion
E-Cadherin Tethered Micropatterned Lipid Bilayers Cell Adhesion
2016/5/24
Cell-cell adhesion is a dynamic process requiring recruitment, binding, and reorganization of signaling proteins in the plane of the plasma membrane. Here, we describe a new system for investigating h...
Cell adhesion to protein-micropatterned-supported lipid bilayer membranes
micropatterning microcontact printing of proteins supported lipid bilayers cell adhesion endothelial cells
2016/5/23
A new method for constructing controlled interfaces between cells and synthetic supported lipid bilayer membranes is reported. Microcontact printing is used to define squares and grid lines of fibrone...
Inhibiting protein clearance to induce cell death in tuberous sclerosis and pancreatic cancer
Ral 4-phenylbutyric acid 4-PBA
2015/5/25
Sequestration at the aggresome and degradation through autophagy are two approaches by which a cell can counteract the toxic effect of misfolded proteins. Tuberous sclerosis (TS) and cancer cells can ...
B cell development and immunoglobulin genes in cattle
Cellular immune globulin genes immune system lymphoid tissue immunoglobulin molecules
2014/12/11
The objective of this dissertation was to study B cell development and the mechanism of immunoglobulin gene diversification in cattle. The bovine immune system differs from that of the mouse and human...
Follicle cell calmodulin: transcript accumulation in vitellogenic follicles of {\it Blattella germanica\/} is regulated by juvenile hormone
Calmodulin cells calmodulin oocytes vitellogenesis early embryo
2014/12/11
Calmodulin (CaM) is a major intracellular calcium receptor. There is abundant calmodulin (CaM) in the oocytes and eggs of B. germanica during vitellogenesis and early embryogenesis. The accumulation o...
{\it CSE1}, an essential yeast gene required for cell cycle progression, encodes a nuclear transport factor
Brewing yeast genes chromosomes genes cell cycle and protein nuclear proteins
2014/12/11
CSE1, an essential Saccharomyces cerevisiae gene was initially isolated in a screen for genes important for accurate chromosome segregation. cse1 mutants have pleiotropic phenotypes including defects ...
The influence of WC1 isoforms on gammadelta T cell function
Scavenger receptor WC1 molecules diversity rich cysteine membrane surface glycoprotein T cells
2014/12/11
WC1 molecules are an extensively diversified family of integral type 1 scavenger receptor cysteine rich (SRCR) membrane glycoproteins expressed on the surface of arteriodactyls such as sheep, cattle, ...
Investigations of glycoprotein co-translational maturation in the cell
New protein Protein Endoplasmic reticulum cavity Protein folding Coupling molecules Fold the sensor Membrane glycoprotein
2014/12/11
The earliest steps of nascent protein folding are critical to the overall folding efficiency. Folding events start as soon as the protein is translocated into the endoplasmic reticulum lumen, where th...
A new framework for identifying combinatorial regulation of transcription factors: a case study of the yeast cell cycle
framework identifying combinatorial regulation transcription factors yeast cell cycle
2010/11/15
By integrating heterogeneous functional genomic datasets, we have developed a new framework for detecting combinatorial control of gene expression, which includes estimating transcription factor activ...
THE INHIBITOR-OF-APOPTOSIS PROTEIN SURVIVIN INCREASES P34CDC2 PHOSPHORYLATION AND ENHANCES CELL SURVIVAL AND PROLIFERATION BY PROTECTING THE WEE1 KINASE FROM DEGRADATION BY CASPASE-3
p34Cdc2 Survivin Wee1 Caspase-3 Apoptosis
2015/5/21
The anti-apoptotic protein Survivin and the cyclin-dependent kinase p34Cdc2 are involved in cell cycle progression and apoptosis. Activation of Cdc2 is required for its pro-apoptotic activity, which c...