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GCN2和mTORC1信号路径对动物机体氨基酸平衡的调节作用
氨基酸平衡 信号途径 GCN2 mTORC1
2018/4/2
氨基酸平衡对哺乳动物健康生长具有重要意义，而在维持机体氨基酸平衡的过程中，GCN2和mTORC1信号路径发挥着重要作用。GCN2路径能有效感应胞内氨基酸缺乏，而mTORC1路径则能对胞外氨基酸水平的变化做出响应。本文结合近年来有关GCN2和mTORC1的研究进展，阐述了氨基酸充足和氨基酸饥饿条件下，GCN2和mTORC1这两条信号路径的感应特点以及随后启动的相关应答机制，包括蛋白质合成、拒食行为、...
Regulation of mTORC1 by growth factors,energy status,amino acids and mechanical stimuli at a g lance
mTORC1 Akt Myostatin Muscle protein synthesis
2016/5/16
The mechanistic/mammalian target of rapamycin c omplex 1 (mTORC1) plays a pivotal r ole in the regulation of skeletal muscle protein synthesis. A ctivation of the c omplex leads to phosphorylation of ...
Patients with the genetic disorder tuberous sclerosis complex (TSC) suffer from neoplastic growths in multiple organ systems. These growths are the result of inactivating mutations in either the TSC1 ...