搜索结果: 1-15 共查到“知识库 drug”相关记录281条 . 查询时间(0.11 秒)
A novel tissue-engineered 3D tumor model for anti-cancer drug discovery
decellularized porcine lung matrix breast tumor model biocompatibility CARS drug resistance
2023/3/1
Cancer biology and drug discovery are heavily dependent on conventional 2D cell culture systems. However, a 2D culture is significantly limited by its ability to reflect 'true biology' of tumor in viv...
Structural Basis for the Inhibition of SARS-CoV-2 Main Protease by Antineoplastic Drug Carmofur
SARS-CoV-2 cross-neutralizing antibody receptor binding motif spike protein substitution mutation
2020/6/11
The antineoplastic drug carmofur is shown to inhibit the SARS-CoV-2 main protease (Mpro). Here, the X-ray crystal structure of Mpro in complex with carmofur reveals that the carbonyl reactive group of...
The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro
The anti-influenza virus drug arbidol efficient inhibitor SARS-CoV-2 in vitro
2020/6/11
Since December 2019, a novel disease COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread to over 200 countries and infected over 1.50 million people includin...
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
Structure-based design antiviral drug candidates targeting SARS-CoV-2 protease
2020/6/12
SARS-CoV-2 is the etiological agent responsible for the global COVID-19 outbreak. The main protease (Mpro) of SARS-CoV-2 is a key enzyme that plays a pivotal role in mediating viral replication and tr...
Wildlife and Drug Trafficking, Terrorism, and Human Security
Wildlife Drug Trafficking Terrorism Human Security
2019/10/11
The planet is experiencing alarming levels of species loss caused in large part by intensified poaching stimulated by a greatly expanding demand for animals, plants, and wildlife products. The rate of...
Short-term effects of a progestational contraceptive drug on food intake, resting energy expenditure, and body weight in young women
menstrual cycle depot medroxyprogesterone acetate contraception
2016/6/12
Studies showed that hormonal fluctuations that
occur over the human menstrual cycle affect energy intake and
expenditure. However, little is known about the possible effects
on body weight regulati...
Dietary supplements, used widely by Americans, are regulated
by the Dietary Supplement Health and Education Act of 1994
(1), an amendment to the Federal Food, Drug and Cosmetic Act.
The Dietary Sup...
A mechanism on the drug release into a perfect sink from a coated planar matrix with a super-saturation loading in the core
Coated planar matrix Controlled release Mathematical analysis In-vitro release
2016/3/25
A comprehensive model is proposed to accurately describe drug release kinetics from a coated plane sheet when drug loading in the core is above its saturation level. The general solutions are acquired...
An Analysis of the Medicare Prescription Drug Benefit
Medicare Prescription drugs Health production Dynamic discrete choice Moral hazard
2016/3/18
Medicare has recently experienced the largest expansion of benefits since its in- ception: the inclusion of prescription drug coverage under the Medicare Prescription Drug, Improvement and Modernizati...
A Meta-Analysis of Randomized Clinical Trials Comparing Shorter (Less or Equal Than 6 Months) and Longer (More or Equal Than 12 Months) Dual Anti-Platelet Therapy Following Drug-Eluting Coronary Stents
Drug-Eluting Stents Dual Antiplatelet Therapy Meta-Analysis
2015/11/9
Context: The optimal duration of dual anti-platelet therapy (DAPT) after the implantation of drug-eluting coronary stents (DES) is still the subject of ongoing debate. This meta-analysis was performed...
This study assessed an in-school program aimed at preventing or reducing drug use and other deviant behavior in a sample of 167 at-risk youth in their transition years. Over 10 weeks, 17 one-hour sess...
The Effect of Prescription Drug Advertising on Doctor Visits
Doctor Visits Drug Advertising
2015/9/21
The dramatic increase of direct-to-consumer advertising (DTCA) of prescription drugs created intensive debates on its effects on patient and doctor
behaviors. Combining 1994–2000 DTCA data with the 1...
Drug Resistance in Salmonella typhi: Tip of the Iceberg
Drug resistance Plasmid Salmonella typhi
2015/7/30
Salmonella typhi is one of the most resistant organisms with multi-drug resistant strains reported from many countries. Initially, individual plasmids were known to code for resistance,but since 1988 ...
A Fifty-year challenge in managing drug addiction in Malaysia
Fifty-year challenge drug addiction Malaysia
2015/7/28
The history of substance abuse in Malaysia can be divided into pre- and post-independent era. In pre-independence, the main drug of abuse was opium which was initially consumed by immigrants from Chin...
Sphingosomes a novel approach to vesicular drug delivery
sphingosomes drug delivery sphingomyelin vesicular system
2015/7/21
Vesicular systems have been realized as extremely useful carrier systems in various scientific domains. Sphingosomes is bilayered vesicles in which an aqueous volume is entirely enclosed by membrane l...