搜索结果: 1-15 共查到“知识库 Immunotherapy”相关记录41条 . 查询时间(0.125 秒)
Journal for ImmunoTherapy of Cancer丨罗敏/卢智刚团队报道瘤内注射激活STING的纳米疫苗提高抗肿瘤免疫效果（图）
卢智刚团队 肿瘤免疫 生物医学研究院
2023/4/14
整合含有天然免疫刺激分子的纳米制剂、以及个性化新抗原筛选技术，使肿瘤疫苗在临床测试展现了令人瞩目的有效性。新一代的肿瘤疫苗与CAR技术﹑免疫检查点干预成为免疫治疗中重要的三大板块。然而，在很多病人中，T细胞无法通过肿瘤屏障进入瘤内，导致对多种免疫治疗的不敏感；因此促进T细胞进入肿瘤，逆转肿瘤微环境成为提高免疫治疗效果的重要步。
徐建青、张晓燕教授团队《Journal for ImmunoTherapy of Cancer》报道一种全新的、肿瘤微环境激活杀伤的CAR-T，有潜力成为不同实体瘤有效治疗手段（图）
张晓燕教授 生物医学研究院 实体瘤 CAR-T疗法
2023/4/14
近年来，CAR-T疗法治疗血液源性肿瘤效果显著，然而在针对实体瘤的临床研究中却遭遇重大挑战。目前CAR-T均为靶点激活杀伤，而肿瘤靶点通常也在正常组织低表达，进而产生“on-target, off-tumor”现象、诱生炎症因子风暴、中枢神经毒性等，给CAR-T治疗带来严重的安全隐患。肿瘤细胞的异质性进一步导致靶点激活杀伤有效性受到挑战。即目前的靶点激活杀伤的CAR-T技术在在治疗实体瘤中，安全性...
许杰课题组《Journal for Immunotherapy of Cancer》揭示THADA在驱动PD-L1高尔基体驻留中的作用以及肿瘤免疫靶标价值（图）
许杰课题组 癌细胞 免疫检查点
2023/4/17
癌细胞中程序性死亡配体1（PD-L1）的异常上调抑制T细胞介导的细胞毒性，但驱动和维持PD-L1表达的分子机制仍不完全清楚。PD-L1在肿瘤细胞内高尔基体等细胞器的驻留可能是影响抗体药物疗效的因素之一，但既往对其理解并不充分，使免疫检查点阻断疗法面临挑战。
徐建青/张晓燕团队在《Journal for ImmunoTherapy of Cancer》报道IL-21重组溶瘤痘苗病毒单独或联合免疫细胞疗法具有强效抗肿瘤作用（图）
溶瘤病毒 冷肿瘤 热肿瘤 牛痘病毒天坛株
2023/4/17
溶瘤病毒是天然的或经人工改造的、能在肿瘤组织中优势复制、直接或间接抑制肿瘤细胞生长的一类病毒。溶瘤病毒主要通过以下途径发挥抗肿瘤功能：（1）病毒在肿瘤细胞内复制导致肿瘤细胞直接杀伤；（2）病毒感染肿瘤细胞后激发并释放细胞因子，重塑肿瘤免疫微环境、趋化免疫细胞浸润到肿瘤组织，促进“冷肿瘤”向“热肿瘤”转变；（3）裂解的肿瘤细胞释放特异性抗原，与细胞因子协同，提升机体抗肿瘤特异性免疫反应；（4）溶瘤病...
树突状细胞（DC）疫苗是目前在临床上应用的一种肿瘤治疗疫苗，其制备过程一般都在病人体外进行，病人来源的DC在体外进行诱导分化后再回输给病人，这种疫苗制备过程十分复杂，容易被污染，不同的技术人员、不同条件的实验室制备的疫苗疗效差异较大，较难标准化，因此体外制备的DC疫苗很难在临床推广应用。
2020年4月16日，Journal for ImmunoTherapy of Cancer (JITC)杂志在线发表了上海交通大学医学院上海市免疫学研究所李斌课题组和复旦大学附属妇产科医院乳腺外科吴克瑾课题组合作的成果“Targeting ANXA1 abrogates Treg-mediated immune suppression in triple-negative breast canc...
New systemic therapies for metastatic melanoma – mapk inhibitors and immunotherapy
metastatic melanoma mapk inhibitors
2015/4/7
Metastatic melanoma has a poor prognosis and until recently systemic therapy was ineffective. Advances in the
understanding of tumour biology and immune regulation have led to the development of tar...
Immunotherapy of melanoma – past, present and future
past present future Immunotherapy melanoma
2015/3/18
Treatment of melanoma by immunotherapy remains a topic of much interest. Initial studies were based on stimulation of
immune responses by immunisation with whole cells or lysates of whole cells. Some...
Cancer immunotherapy aims to exploit and maximise the body’s
own immune system in order to target and destroy cancer cells.
The immune system is a complex and effective integrated
network of specia...
Immunotherapy of melanoma
melanoma Immunotherapy
2015/3/11
Melanoma is a cruel disease. The most recent Australian figures
indicate that over 8000 cases of melanoma were reported in
1997 and that approximately 900 people died of the disease
that year+
. O...
Dendritic cell biology and application for tumour immunotherapy
tumour immunotherapy Dendritic cell biology
2015/3/11
The dendritic cell (DC), an uncommon type of bone marrowderived leukocyte, is widely acknowledged as the most
effective antigen presenting cell (APC) and has the unique
capacity to initiate and cont...
Soypeptide lunasin in cytokine immunotherapy for lymphoma
lunasin cancer immunotherapy lymphoma NK cell natural killer
2015/5/22
Immunostimulatory cytokines can enhance anti-tumor immunity and are part of the therapeutic armamentarium for cancer treatment. We previously reported that chemotherapy-treated lymphoma patients acqui...
Overcome the Impairment of NK Cells for Icon and Antibody Immunotherapy of Cancer
Natural Killer Cells Antibody Cancer Immunotherapy Icon Dietary Supplements
2013/1/30
Natural killer (NK) cells play an important role in innate immunity and in mediating antibody and Icon (an antibody-like factor VII/IgG1 Fc immunoconjugate, which, to our best knowledge, was the first...
TRP-1 AS A MODEL TUMOR ANTIGEN FOR IMMUNOTHERAPY AND IMMUNE TOLERANCE IN THE THYMUS
immune tolerance T cells mTECs
2015/5/21
Tolerance mechanisms, which collectively work to prevent autoimmunity, play a key role in suppressing the adaptive immune response to tumor antigens. This phenomenon is attributed to the extensive ove...
Antigen-Specific Immunotherapy against Allergic Rhinitis: The State of the Art
allergic rhinitis biomarker immunotherapy pollinosis regulatory T cell
2010/11/12
Allergic rhinitis is the most prevalent type I allergy in industrialized countries. Pollen scattering from trees or grasses often induces seasonal allergic rhinitis, which is known as pollinosis or ha...