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Next-gen sequencing identifies non-coding variation disrupting miRNA binding sites in neurological disorders
SCZ ASD
2017/8/28
Understanding the genetic factors underlying neurodevelopmental and neuropsychiatric disorders is a major challenge given their
prevalence and potential severity for quality of life. While large-scal...
Abstract
Timothy E. Breen Ph.D.
A DATABASE FOR NUCLEAR RECEPTOR DNA BINDING SITES
A database has been developed for nuclear receptor DNA binding sites and the corresponding nuclear receptor DNA ...
Effect of atrazine and zearalenone on the numer of receptor binding sites for 3H-estradiol in the rat uterus cytosol
atrazine zearalenone 3H-estradiol receptor ovary uterus rat
2015/1/26
The effect of a daily dose of 14 mg atrazine and/or 2.5 mg zearalenone that were administered to rats during 5 days of estrous cycle on the number of receptor binding sites for 3H-estradiol in uterine...
Inhibition of protein synthesis in Escherichia coli by expression of RNAs containing multiple ribosome binding sites
To get together the biosynthesis of chemical biological synthesis mRNA
2014/12/11
Biologically synthesized poly(α,L-glutamic acid) (PLGA) can be chemically modified to form monodisperse poly(γ-benzyl α,L-glutamate) (PBLG). This material shows rare smectic ordering where macromolecu...
Identification of the Pba1 and Pba2 Binding Sites on 20S Core Particle Intermediates
Molecular Biology
2015/5/22
The proteasome is responsible for breaking down the majority of the proteins in the cell. However, a complete understanding of how this large multi-subunit protease is assembled is currently lacking. ...
Ion Binding Sites and their Representations by Quasichemical Reduced Models
Ion Binding Sites Representations Quasichemical Reduced Models
2012/2/27
The binding of small metal ions to complex macromolecular structures is typically dominated by strong local interactions of the ion with its nearest ligands. For this reason, it is often possible to u...
Design of novel carbamate acetylcholinesterase inhibitors based on the multiple binding sites of acetylcholinesterase
Plant Diseases Insect Pests Plant Protection
2009/3/5
This work describes the design, synthesis, AChE inhibitory activity, and structure-activity relationship of compounds related to a recently discovered series of AChE inhibitors: phthalimide alkyloxy...
Cytoplasmic estradiol binding sites in testis of fertile and infertile men
estradiol receptors human testis receptor ontogenesis Leydig cell function human testicular disorders testicular cytosolic receptors
2009/2/20
Free cytoplasmic estradiol receptor was determined in testicular biopsies from six adults showing various primary testicular disorders, and in testicular tissue obtained at autopsy from 18 males of ...
Competition of the Histamine H2 Antagonist Cimetidine for Androgen Binding Sites in Man
cimetidine androgen binding prostate testis
2009/2/18
Gynecomastia and impotence have been described as side-effects of cimetidine therapy. It has previously been shown that cimetidine possesses antiandrogenic properties and competes for dihydrotesto...
Expression of mannose-binding sites on human spermatozoa and their role in sperm-zona pellucida binding
mannose-binding sites human spermatozoa sperm-zona pellucida binding
2009/2/13
A D-mannosylated albumin (DMA) neoglycoprotein was assessed to validate experimentally a probe capable of detecting mannose-binding sperm receptors involved in human sperm-egg interaction. DMA spe...
The Effect of Bovine Somatotropin and Diet on Somatotropin Binding Sites in Hepatic Tissue of Lactating Dairy Cows
binding sites dairy cows liver somatotropin
2008/7/23
In the lactating cow, galactopoiesis is stimulated by treatment with recombinant bovine somatotropin (bST) and by an improved plane of nutrition. The present study determined the interaction between t...
Molecular Structure and Binding Sites of Cobalt(II) Surface Complexes on Kaolinite from X-ray Absorption Spectroscopy
Cobalt EXAFS Kaolinite Sorption Surface complex
2011/12/29
X-ray absorption spectroscopy (XAS) was used to determine the local molecular environment of Co(II) surface complexes sorbed on three different kaolinites at ambient temperature and pressure in contac...