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近日,哥伦比亚大学科研人员在Nature Cell Biology上发表了题为“ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway”的文章,发现ALOX12通过调控一个独特的“铁死亡(ferroptosis)”通路,促进p53介导的肿瘤抑制。
![](http://www.firstlight.cn/upload/imgfile/201710/25/20171025155659246.jpg)
P53 “master switch” remains top target in gene signaling network controlling cancer suppression(图)
P53 master switch top target gene signaling network controlling cancer suppression
2017/10/25
There are two important categories of genes involved in cancer development, oncogenes and tumor suppressor genes. When oncogenes gain function, e.g. through mutation, they actively promote cancer – dr...
《癌细胞》:美研究发现脑癌与肿瘤抑制基因p53缺陷有关
脑癌 肿瘤 基因
2009/6/10