搜索结果: 1-14 共查到“国际动态 生物工程 CRISPR”相关记录14条 . 查询时间(0.109 秒)
New CRISPR-based tool inserts large DNA sequences at desired sites in cells（图）
CRISPR 新型工具 大DNA序列 PAST 基因工程
2023/6/21
Building on the CRISPR gene-editing system, MIT researchers have designed a new tool that can snip out faulty genes and replace them with new ones, in a safer and more efficient way.
The Human Genome Project was an ambitious initiative to sequence every piece of human DNA. The project drew together collaborators from research institutions around the world, including MIT's Whitehea...
江苏省作物基因组学和分子育种重点实验室基因编辑团队在Plant Biotechnology Journal发布论文，系统评估了PAM松弛型CRISPR-Cas9植物基因组编辑工具的脱靶效应，提示ABE8e存在高比例脱靶
CRISPR-Cas9 基因编辑 水稻 脱靶效应
2023/8/9
CRISPR-Cas9基因编辑工具凭借其高效、易用、灵活特性极大的改变了传统育种手段，研究人员为了扩大其靶向范围，设计了一系列SpCas9变体，包xCas9（识别5′-NG-3′、5′-GAA-3′、5′-GAT-3′ PAM）、SpCas9-NGv1和SpCas9-NG（识别5′-NG-3′ PAM）以及PAM-less SpRY然而，这些PAM-relaxed Cas9核酸酶是否会造成向导RN...
Researchers at MIT’s McGovern Institute for Brain Research have discovered a bacterial enzyme that they say could expand scientists’ CRISPR toolkit, making it easy to cut and edit RNA with the kind of...
New programmable gene editing proteins found outside of CRISPR systems（图）
CRISPR系统 可编程基因 编辑蛋白 酶
2023/6/20
Within the last decade, scientists have adapted CRISPR systems from microbes into gene editing technology, a precise and programmable system for modifying DNA. Now, scientists at MIT’s McGovern Instit...
《细胞》杂志9日在线发表的一篇论文表示，美国怀特黑德研究所乔纳森·魏斯曼等人设计了一种名为CRISPRoff的新基因编辑技术，可以在不改变DNA序列的情况下使某些基因“沉默”，从而以高特异性控制基因表达。这种“升级版”的基因编辑技术为研究表观遗传机制、重大疾病治疗以及研发新冠病毒疫苗等提供了有力工具。
Nature-inspired CRISPR enzymes for expansive genome editing（图）
CRISPR酶 基因组编辑 应用计算生物学 DNA序列
2023/6/19
In nature, bacteria use CRISPR as an adaptive immune system to protect themselves against viruses. Over the past decade, scientists have been able to successfully build upon that natural phenomenon wi...
Discovery Helps Engineer More Accurate Cas9s For Crispr Editing（图）
Engineer Cas9s Crispr Editing
2017/10/24
Scientists at the University of California, Berkeley and Massachusetts General Hospital have identified a key region within the Cas9 protein that governs how accurately CRISPR-Cas9 homes in on a targe...
Off-Switch for CRISPR-Cas9 Gene Editing System Discovered
Off-Switch CRISPR-Cas9 Gene Editing System
2017/1/9
UC San Francisco researchers have discovered a way to switch off the widely used CRISPR-Cas9 gene-editing system using newly identified anti-CRISPR proteins that are produced by bacterial vi...
CRISPR-Cas adaptive immune systems in prokaryotes boast a diversity of protein families and mechanisms of action, where most systems rely on protospacer-adjacent motifs (PAMs) for DNA target recogniti...
CRISPR-Cas9 gene editing:check three times,cut once
CRISPR-Cas9 gene editing check three times cut once
2015/12/7
Two new studies from UC Berkeley should give scientists who use CRISPR-Cas9 for genome engineering greater confidence that they won’t inadvertently edit the wrong DNA.The gene editing technique, creat...
Controlling genes using CRISPR shows high degree of specificity
Controlling genes CRISPR high degree of specificity
2015/11/12
Researchers have demonstrated the exceptional specificity of a new way to switch sequences of the human genome on or off without editing the underlying genetic code.Originally discovered as an antivir...
Researchers Use DNA‘Clews’to Shuttle CRISPR-Cas9 Gene-Editing Tool into Cells
Researchers DNA Clews Shuttle CRISPR-Cas9 Gene-Editing Tool
2015/9/8
CRISPR–Cas9 represents a promising platform for genome editing, yet means for its safe and efficient delivery remain to be fully realized. A novel vehicle that simultaneously delivers the Cas9 protein...
New technique uses bacteria's own CRISPR-Cas system to turn off genes
bacteria genes CRISPR-Cas system
2014/10/30
Researchers from North Carolina State University have developed a technique that co-opts an immune system already present in bacteria and archaea to turn off specific genes or sets of genes – creating...