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Multiple myeloma is an incurable bone marrow cancer that kills over 100,000 people every year. Known for its quick and deadly spread, this disease is one of the most challenging to address. As these c...
Fibrosis is the thickening of various tissues caused by the deposition of fibrillar extracellular matrix (ECM) in tissues and organs as part of the body’s wound healing response to various forms of da...
Bone and soft tissue sarcomas are rare, accounting for approximately 1% of all adult solid malignant tumors. Although these cancers are categorised under the same banner of ‘sarcoma’, they in fact rep...
Bone is a common site for cancer metastasis. The development of bone metastases represents a serious progression in a patient with cancer, leading to treatment goals changing from curative to palliati...
Bone sarcomas are the fourth most common cancer in individuals under 25 years. Osteosarcoma is the most common form of sarcoma in this population, with distal femur the most common tumour location. Be...
The biopsy of bone and soft tissue sarcoma is an integral part in the management of patients with these disorders and inadequate, inappropriate or inaccurate non-representative biopsies do lead to poo...
The standard for local control of malignant bone and soft tissue tumours has been amputation. Advances in multimodality treatment have seen a shift towards preservation of the limb. Sophisticated tech...
The role of radiology in assessing bone and soft tissue sarcomas encompasses the initial detection and diagnosis of the lesion, staging the lesion both locally and systemically, guiding biopsy of the ...
We have shown that nuclear matrix protein 4 (Nmp4) attenuates the response to intermittent parathyroid hormone (PTH) in healthy and ovariectomized (OVX) female mice using a global knockout of the Nmp4...
Treatment of bone metastases comprises over 10% of the workload of a radiation-oncology center. Bone metastases produce severe pain and immobility, necessitate narcotic use, and reduce the quality of ...
I n this paper pour cases of aneurysmal bone cyst are reported and the different etiological factors considered. We believe that aneurysmal bone cyst disease entity with pathologica radiological and c...
The identification of tumor antigens recognized by cytotoxic T-lymphocytes and subsequent clinical trials using peptide immunization have shown tumor regression in advanced malignant melanoma patients...
Chondromyxoid fibroma (CF) is an uncommon benign primary bone tumor that was first described by Jaffe and Lichtenstein in 1948 (1). CF usually originates from the long bones of young adults, but has b...
In the present study involving patients with bone metastases arising from prostate cancer, we measured urinary deoxypyridinoline (DPD) as a marker of collagen breakdown activity, serum total and bone-...

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