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IL-10 and IL-13 Production by Peripheral Blood Mononuclear Cells in Patients with Diabetes Mellitus
IL-10 IL-13 diabetes mellitus
2009/6/16
Aim: It is generally accepted that proinflammatory cytokines secreted by mononuclear cells are responsible for pancreatic beta (B) cell destruction in animal models of autoimmune type-1 diabetes melli...
Spontaneous production of interleukin-5 and its heterogeneous effect on eosinophils in an adult T-cell leukemia patient
adult T-cell leukemia eosinophil heterogeneity interleukin-5
2010/11/25
We examined the functional heterogeneity of eosinophils from an adult T-cell leukemia (ATL) patient with eosinophilia. A 63-year-old man was admitted to our hospital because of lymphadenopathy. The le...
Interleukin-10 inhibits the production of inflammatory cytokines by antigen-stimulated mononuclear cells from asthmatic patients
bronchial asthma granulocytemacrophage colony stimulating factor interferon-γ interleukin-1β interleukin-2 interleukin-5 interleukin-10
2010/11/25
Bronchial asthma, characterized by chronic airway inflammation, involves many inflammatory cytokines. Interleukin (IL)-10 is a potent inhibitor of cytokine synthesis. Thus, the effects of IL-10 were e...
Low-dose exogenous interleukin (IL)-12 enhances antigen-induced interferon-γ production without affecting IL-10 production in asthmatics
bronchial asthma Dermatophagoides farinae interferon-γ interleukin-10 interleukin-12 peripheral blood mononuclear cells
2010/11/25
The production of IFN-γ by PBMC was significantly enhanced by incubation with IL-12 in both patient groups (P < 0.05), while IL-12 did not affect the production of IL-10 in either group. Lymphocyte pr...
Induction of inducible nitric oxide synthase mRNA expression and nitric oxide production from macrophages stimulated with high-molecular size mite antigen HM1
airway inflammation high-molecular size mite antigen HM1 inducible nitric oxide synthase nitric oxide
2010/11/24
Gene expression of TNF-α, IL-12 p40 and iNOS was observed with HM1 stimulation of splenic macrophages from non-immunized mice. In addition, the release of NO induced by HM1-stimulated splenic macropha...