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Smart Artificial Beta Cells Could Lead to New Diabetes Treatment（图）
Smart Artificial Beta Cells New Diabetes Treatment
2017/11/23
Treating type 1 diabetes and some cases of type 2 diabetes has long required painful and frequent insulin injections or a mechanical insulin pump for insulin infusion. But researchers from the Univers...
In Huntington’s Disease,Traffic Jams in The Cell’s Control Center Kill Brain Cells
In Huntington’s Disease The Cell’s Control Center Kill Brain Cells
2017/7/19
Working with mouse, fly and human cells and tissue, Johns Hopkins researchers report new evidence that disruptions in the movement of cellular materials in and out of a cell’s control center — the nuc...
Toeing the Line:Study finds brain cells that signal path of travel
brain cells signal path travel
2017/1/9
Imagine you’re navigating a city like New York, or any other that’s laid out on a grid. Suppose you run into a roadblock as you’re heading north. How do you know that you can turn to your left, say, a...
Exercise on Progenitor Cells in Healthy Subjects and Patients with Type 1 Diabetes
DIABETES BLOOD CIRCULATION ENDOTHELIUM
2017/4/13
Purpose: To evaluate the acute effect of aerobic exercise (AE) and resistance exercise (RE) on the release of endothelial progenitor cell (EPCs, CD34+/KDR+/CD45dim) and vascular function in type 1 dia...
Prenatal Maternal Physical Activity and Stem Cells in Umbilical Cord Blood
REAST STEM CELLS CARDIOVASCULAR FITNESS EARLY LIFE DETERMINANTS
2017/4/13
Purpose: Early life processes, through influence on fetal stem cells, affect postnatal and adult health outcomes. This study examines the effects of physical activity before and during pregnancy on st...
Warming-Up Affects Performance and Lactate Distribution between Plasma and Red Blood Cells
Lactate concentration blood performance enhancement anaerobic exercise cycling competition preparation
2015/5/5
Warming-up (WU) is a widely used preparation for training and competition. However, little is known about the potential mechanisms of WU on performance and on the lactate distribution in the blood com...
Mesenchymal Stem Cells Augment the Adaptive Response to Eccentric Exercise
A7 INTEGRIN SATELLITE CELLS STEM CELL ANTIGEN-1 DOWNHILL RUNNING REPAIR GROWTH
2017/4/14
Purpose: The α7β1 integrin is a transmembrane protein expressed in the skeletal muscle that can link the actin cytoskeleton to the surrounding basal lamina. We have previously demonstrated that transg...
Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain
APE1 DNA repair hematopoiesis
2014/12/12
Ape1 is a molecule with dual functions in DNA repair and redox regulation of transcription factors. In Ape1-deficient mice, embryos do not survive beyond embryonic day 9, indicating that this molecule...
Lack of EGF receptor contributes to drug sensitivity of human germline cells
DNA damage epidermal growth factor receptor drug resistance
2014/12/12
Germline mutations have been associated with generation of various types of tumour. In this study, we investigated genetic alteration of germline tumours that affect the drug sensitivity of cells. Alt...
Protection of pulmonary epithelial cells from oxidative stress by hMYH adenine glycosylase
oxygen toxicity hMYH adenine glycosylase
2014/12/12
Background: Oxygen toxicity is a major cause of lung injury. The base excision repair pathway is one of the most important cellular protection mechanisms that responds to oxidative DNA damage. Lesion-...
Role of the Multifunctional DNA Repair and Redox Signaling Protein Ape1/Ref-1 in Cancer and Endothelial Cells: Small-Molecule Inhibition of the Redox Function of Ape1
APE1/Ref-1 redox signaling cancer
2014/12/12
The DNA base excision-repair pathway is responsible for the repair of DNA damage caused by oxidation/alkylation and protects cells against the effects of endogenous and exogenous agents. Removal of th...
Role of Ape1 and Base Excision Repair in the Radiation Response and Heat-radiosensitization of HeLa Cells
radiation hyperthermia DNA repair
2014/12/12
Background: The mechanism by which heat sensitizes mammalian cells to ionizing radiation remains to be elucidated. We determined whether base excision repair (BER) is involved in heat-radiosensitizati...
Protection of Human Lung Cells against Hyperoxia Using the DNA Base Excision Repair Genes hOgg1 and Fpg
oxygen toxicity DNA damage DNA repair
2014/12/12
Hyperoxia causes pulmonary toxicity in part by injuring alveolar epithelial cells. Previous studies have shown that toxic oxygen-derived species damage DNA and this damage is recognized and repaired b...
Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress; Use of APE1 small molecule inhibitors to delineate APE1 functions
base excision repair APE1/Ref-1 oxidative stress
2014/12/12
Oxidative DNA damage has been implicated in a number of central nervous system pathologies. The base excision repair (BER) pathway is one of the most important cellular protection mechanisms that resp...
Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells
APE1/Ref-1 cell signaling difference analysis
2014/12/12
Apurinic apyrimidinic endonuclease/redox effector factor 1 (APE1/Ref-1) protects cells from oxidative stress by acting as a central enzyme in base excision repair pathways of DNA lesions and through i...