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DACS‐DB: AN ANNOTATION AND DISSEMINATION MODEL FOR DISEASE ASSOCIATED CYTOKINE SNPs
Cytokine SNP Disease
2015/5/26
Cytokines mediate crucial functions in innate and adaptive immunity. They play valuable roles in immune cell growth and lineage specification, and are associated with various disease pathologies. A la...
Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection
Endothelial Cells Central Orchestrators Cytokine Amplification
2012/2/1
Cytokine storm during viral infection is a prospective predictor of morbidity and mortality, yet the cellular sources remain undefined. Here, using genetic and chemical tools to probe functions of the...
Immunoregulatory Cytokine (TGF-ß And IL-10) Responses in Mice Inoculated With Protoscoleces and Major Hydatid Fluid Antigens of Cystic Echinococcosis
Echinococcus granulosus Protoscolex AgB TGF-β IL-10
2009/12/7
Background: Our objectives were to investigate whether immunomodulatory cytokines, TGF-β and IL-10, are stimulated in response to cystic echinococcosis (CE) components in mice model, and whether major...
Gamma-globulin Inhibits Superantigen-induced Lymphocyte Proliferation and Cytokine Production
neutralizing antibody pooled human immunoglobulin Staphylococcal enterotoxin B superantigen
2010/11/18
Background: High-dose pooled human immunoglobulin (PHIG) treatment is sometimes effective in superantigen related inflammatory diseases, such as toxic shock syndrome and Kawasaki disease. Neutralizing...
Lactobacillus Acidophilus Strain L-92 Regulates the Production of Th1 Cytokine as well as Th2 Cytokines
Lactobacillus acidophilus strain L-92 Peyer's patch splenocytes TGF-β Treg
2010/11/18
Oral L-92 administration regulated both Th1 and Th2 cytokine responses, suppressed serum OVA-specific IgE, and induced TGF-β production in PPs. TGF-β is known to be associated with activation of regul...
Air Pollution Induced Asthma and Alterations in Cytokine Patterns
Air Pollution Asthma Cytokines
2010/2/4
In recent decades, clinicians and scientists have witnessed a significant increase in the prevalence of allergic rhinitis and asthma. The factors underlying this phenomenon are clearly complex; howeve...
Structural and functional analysis of a new cytokine, ML-1 (interleukin-17F)
airway inflammation cytokine network interleukin-17 family mitogen-activated protein kinase
2010/11/24
Recent large-scale sequencing of the human genome has facilitated novel gene discovery. A novel gene, ML-1 (interleukin (IL)-17F), was identified from a human expressed sequence tag (EST) sequence, a ...
Effects of ultraviolet-inactivated herpes simplex virus type I on atopic dermatitis-like lesions in NC/Nga mice: Role of the suppressor of cytokine signaling in the skin
atopic dermatitis herpes simplex virus suppressor of cytokine signaling (SOCS) Th1 Th2
2010/11/22
Ultraviolet-inactivated HSV treatment would appear to induce a Th1 cellular response and downregulate that of the Th2 pathway in AD-like lesions of NC/Nga mice by bringing about a reduction of SOCS3 e...
Comparison of local cytokine gene expression and the distribution of eosinophils and CD4-positive cell subsets in the paranasal sinus mucosa between atopic and non-atopic subjects
allergic rhinitis CCR4 CD4 chronic sinusitis CXCR3 cytokines eosinophils
2010/11/22
These results indicate that high expression of Th2-type cytokines concomitant with the infiltration of a predominant number of CD4+ cells and their Th2 subsets play a role in the pathogenesis of eosin...
Latex allergy in a dental nurse: Late nasal response is associated with eosinophil recruitment and T helper 2 cell type cytokine mRNA expression
eosinophils late nasal responses latex allergy T cells Th2 type cytokine
2010/11/29
The occupational uses of latex gloves may be associated with allergic rhinitis. Hypersensitivity to latex has been shown to be IgE-mediated. However, late nasal responses to latex have not been report...
Bronchial and nasal responsiveness in atopic asthma and allergic rhinitis patients: Relationship of local responsiveness to cytokine production by peripheral blood mononuclear cells
allergic rhinitis atopy bronchial asthma bronchial responsiveness interleukin-4 interleukin-5 nasal responsiveness
2010/11/29
To investigate the relationship between local responsiveness and allergic symptoms, bronchial and nasal responsiveness were measured in the following four groups of subjects: (i) bronchial asthma pati...
BASIC AND LABORATORY SCIENCES MURINE CYTOKINE PATTERNS FOLLOWING RUBELLA VACCINATION
cytokine production pattern Takahashi vaccine Cell medi¬ ated immunity
2010/4/27
Although thorough studies on the immune reponse to rubella have been per¬formed, less attention has been given to the cellular mechanism and mediators that shape the process. Specifically, informa...