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观察芍药苷通过白细胞介素13(IL-13)信号转导通路调控3T3成纤维细胞的细胞激活、增殖和胶原产生。 方法 分别用不同浓度的芍药苷(200、 400、 600、 800和1 000 mg/L)或重组白介素13(rIL-13, 6.25、 12.5、 50、100和200 μg/L),在体外刺激经无血清培养基培养12 h的3T3细胞,同时设空白对照组。培养24 h后,用细胞计数试剂盒-8(CCK...
Signal transducers and activators of transcription 6 (Stat6) variants in childhood and adult asthma
atopy dinucleotide repeat polymorphism interleukin-13 interleukin-4 signal transducers and activators of transcription 6 (Stat6)
2010/11/22
Background: Signal transducers and activators of transcription 6 (Stat6) is a key transcription factor involved in interleukin (IL)-4 and IL-13-mediated biological responses. Recently, we reported the...