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Small-Molecule Hydrophobic Tagging Induced Degradation of HaloTag Fusion Proteins
Degradation of HaloTag Fusion Proteins Small-Molecule Hydrophobic Tagging
2014/11/25
The ability to regulate any protein of interest in living systems with small molecules remains a challenge. We hypothesized that appending a hydrophobic moiety to the surface of a protein would mimic ...
Epitope tagging has been widely
used for studies of protein structure and
function (8). The epitope tagging
process generally begins with a cDNA
encoding the protein of interest. A major
weakness...