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LSD1-LIKE1-mediated H3K4me2 demethylation is required for homologous recombination repair
H3K4me2 genome stability LYSINE-SPECIFIC DEMETHYLASE1-LIKE1 homologous recombination
2024/2/29
Homologous recombination is a key process for maintaining genome integrity and diversity. In eukaryotes, the nucleosome structure of chromatin inhibits the progression of homologous recombination. The...
Sex- and species-dependent difference of methoxychlor O-demethylation by rat and mouse liver microsomes
sex difference species difference enantioselective metabolism cytochrome P450
2009/3/5
The in vitro metabolism of methoxychlor (MXC) and its mono-demethylated metabolites (mono-OH-MXC, including (R)- and (S)-enantiomers), was investigated using liver microsomes from rats and mice to r...