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2023年8月29日，中国农业大学国家玉米改良中心、玉米生物育种全国重点实验室赖锦盛教授团队在Plant Biotechnology Journal 上在线发表了题为“Targeted large fragment deletion in plants using paired crRNAs with type I CRISPR system”的研究论文。该研究利用Type I CRISPR系统，...
近日，安徽农业大学农学院魏鹏程课题组和河南大学作物逆境生物学国家重点实验室陆平利课题组合作在Plant Biotechnology Journal上发表了题为“Genome editing with type II-C CRISPR-Cas9 systems from Neisseria meningitidis in rice”的研究论文。该研究基于两个NmCas9蛋白，Nm1Cas9和NmCa...
Characterization of the Mitochondrial Proteome in Pyruvate Dehydrogenase Kinase 4 Wild-Type and Knockout Mice
Starvation Mitochondria Proteomics PDK4
2015/5/25
The goal of this study was to determine the effect of a PDK4 (pyruvate dehydrogenase kinase isoenzyme 4) knock-out on mitochondrial protein expression. A 2-D gel based mass spectrometry approach was u...
Myeloid cells induce neurofibromatosis type 1 aneurysm formation through inflammation and oxidative stress
Oxidative Stress cre/lox Murine Model Aneurysm
2015/5/25
Neurofibromatosis Type 1 (NF1) is a genetic disorder resulting from mutations in the NF1 tumor suppressor gene. Neurofibromin is the protein product of NF1 and functions as a negative regulator of Ras...
Human Niemann-Pick Type C2 Disease Protein Expression, Purification and Crystallization
Niemann-Pick type C2 NPC2 Structure Expression Crystallization Purification
2014/12/12
Niemann-Pick type C2 (NPC2) protein is a soluble protein that binds unesterified cholesterol. The protein helps transport unesterified cholesterol in tandem with the membrane protein Niemann-Pick type...
A Novel Approach For Stable, Cell-Type Restricted Knockdown of Gene Expression in C.ELEGANS
Biological sciences Cell-type restricted knockdown Gene expression C. elegans
2014/12/10
Removal of protein activity by genetic mutation or pharmacological inhibition has been used extensively to understand the normal function of a protein. However, null mutations eliminate gene function ...
Genes associated with common type of arthritis identified（图）
Genes common type of arthritis
2010/1/11
Six genetic regions associated with a common type of arthritis called ankylosing spondylitis have been identified by an international consortium jointly led by Oxford University.Two genes in particula...
专著信息
书名
“UT-B mutants are predisposed to progressive familial heart block type I in a Chinese family: A novel genetic finding in UT-B mutation associated diseases in humans”,
语种
英文
撰写或编译
作者
赵雪俭,杨宝学,孟艳...
期刊信息
篇名
Evaluating the binding affinities of NF-κB p50 homodimer to the wild-type and single-nucleotide mutant Ig-κB sites by the unimolecular dsDNA microarray.
语种
英文
撰写或编译
作者
Jin K. Wang,Tong X. Li,Y...
Landmark study highlights complex genetic risk factors behind type 2 diabetes
genetics diabetes
2007/4/27
26 April 2007，A UK collaboration of scientists has identified three new genes that predispose individuals to develop type 2 diabetes, bringing scientists a step closer towards understanding what cause...
12 April 2007，A particular gene variant appears to make some individuals more vulnerable to obesity, a risk factor for Type 2 diabetes, according to new research published online 12 April by Science, ...
February 21, 2007，Researchers from the Broad Institute of MIT and Harvard, Lund University and Novartis have announced the completion of a genome-wide map of genetic differences in humans and their re...
Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus
Insulin resistance skeletal muscle adipose tissue weight loss thigh adipose tissue thigh muscle
2016/6/3
Background: Adipose tissue (AT) content of the thigh is generally
not considered to be associated with insulin resistance (IR),
but it is unclear whether the distribution of AT in the thigh is a
de...