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Scientists link ALS progression to increased protein instability（图）
ALS protein instability
2014/12/1
LA JOLLA, CA—October 13, 2014—A new study by scientists from The Scripps Research Institute (TSRI), Lawrence Berkeley National Laboratory (Berkeley Lab) and other institutions suggests a cause of amyo...
Cascades of genetic instability resulting from compromised break-induced replication
Comparative Genomic Hybridization Break-induced Replication Copy Number Variations Chromosomal Rearrangements Double-strand Break Repair Half Crossover Homologous Recombination Non-reciprocal Translocation Half crossover instability cascades DNA double-strand break DNA repair Genetic instabilities Array-CGH
2015/5/22
Break-induced replication (BIR) is a mechanism to repair double-strand breaks (DSBs) that possess only a single end that can find homology in the genome. This situation can result from the collapse of...
结直肠腺瘤的微卫星不稳定状态与相关基因表达的研究Microsatellite Instability and Relative Gene Expressions in Sporadic and Familial Adenomatous Polyposis Adenomas
结肠直肠癌 腺瘤 免疫组织化学 微卫星不稳定性
2008/1/10
摘要 应用微切割-聚合酶链反应-单链长度多态性（PCR-SSLP）的方法，检测59例62个结直肠腺瘤，包括散发性腺瘤及家族性腺瘤性息肉病（FAP）腺瘤在BAT26等16个微卫星基因座在结直肠腺瘤标本的微卫星不稳定性（MSI）状态；并应用免疫组织化学SP法检测β-连接素（β-catenin）、TP53、BAX等的表达情况，初步探讨错配修复（MMR）基因在结直肠癌发生的早期即腺瘤阶段的作用及其意义。结...