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The role of Notch in T cell activation and development
To activate T cells incision p53 intracellular domain HES1 genes
2014/12/11
Notch is crucial for multiple stages of T cell development, including the CD4+CD8+ double positive (DP) to CD8 + single positive (SP) transition, but regulation of Notch activation is not well underst...
Notch-1 regulates IFN-gamma secretion through activation of NF-kappaB
An immune response cell factor cell differentiation T cells activate T cell line
2014/12/11
The cytokine IFN-γ is important in mediating immune responses, while the Notch family of transmembrane receptors has been implicated in modulating T cell differentiation at several stages of developme...
EGFR expression and activation in bovine cumulus cells and EGFR intramolecular regulation through interactions between tyrosines
Epidermal growth factor receptor the process of cell the cell cycle cell migration cell metabolism cell proliferation oocytes and embryo development activation of cumulus cells
2014/12/11
The epidermal growth factor receptor (EGFR) plays important roles in the control of many fundamental cellular processes including cell cycle, cell migration, cell metabolism and survival, cell prolife...
Notch functions from the cytoplasm to the nucleus during T cell activation
Cytokines T cells activate cells cell signal
2014/12/11
Notch1 specifically upregulates expression of the cytokine interferon-γ in peripheral T cells through activation of NF-κB. However, how Notch mediates NF-κB activation remains unclear. NF-κB activatio...
WC1 mediates T cell activation and is required for the response of bovine gammadelta T cells to Leptospira antigen
Biological sciences T cell activation Leptospira
2014/12/11
Workshop cluster 1 (WC1) molecules are exclusively expressed on the surface of γδ T cells. They belong to the scavenger receptor cysteine-rich (SRCR) superfamily and are encoded by a multiple-gene fam...
NON-CANONICAL NOTCH SIGNALING REGULATES ACTIVATION AND DIFFERENTIATION OF PERIPHERAL CD4+ T CELLS
Notch non-canonical T cell NF-kB mTOR activation differentiation cross-talk
2014/12/10
Cleavage of the Notch receptor via a γ-secretase, results in the release of the active intra-cellular domain of Notch that migrates to the nucleus and interacts with RBP-JΚ, resulting in the activatio...
Activation of Src tyrosine kinase in microglia in the rat hippocampus following transient forebrain ischemia
Src Phosphorylation Transient forebrain ischemia Microglia
2014/3/31
o better understand the pathophysiological role of Src protein, a non-receptor protein tyrosine kinase of 60 kDa, in the ischemic brain,
we investigated the time course and regional distribution of a...
Antioxidative treatment prevents activation of death-receptor- and mitochondrion-dependent apoptosis in the hearts of diabetic rats
Antioxidants Apoptosis Cardiovascular disease Diabetes Lipoic acid Streptozotocin.
2014/3/31
Aims/hypothesis. The mechanisms by which glucose
injures cells of the cardiovascular system include gen-eration of reactive oxygen species and induction of
cellular apoptosis. To date, little is kno...