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Bioinformatics and Pharmacogenomics in Drug Discovery and Development
Bioinformatics Pharmacogenomics
2015/5/27
Objective: Literature review to evaluate the extent to which Bioinformatics has facilitated the drug discovery and development process from an economic perspective
Problem: A plethora of genomic and ...
Interplay between mutational pathway and spatial drug distribution controls time to evolution of drug resistance
Interplay mutational pathway spatial drug distribution controls time evolution of drug resistance
2012/2/28
Spatial gradients of drug concentration are believed to play an important role in the evolution of drug resistance. We use a stochastic model to show that in a growing population of malignant cells th...
An acoustically-driven biochip - Impact of flow on the cell-association of targeted drug carriers
acoustically-driven biochip - Impact flow cell-association targeted drug carriers
2011/8/11
Abstract: The interaction of targeted drug carriers with epithelial and endothelial barriers in vivo is largely determined by the dynamics of the body fluids. To simulate these conditions in binding a...
Increasing risk behavior can outweigh the benefits of anti-retroviral drug treatment on the HIV incidence among men-having-sex-with-men in Amsterdam
Increasing risk behavior anti-retroviral drug treatment
2011/1/6
The transmission through contacts among MSM (men who have sex with men) is one of the dominating contributors to HIV prevalence in industrialized countries. In Amsterdam, the capital of the Netherland...