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Neurexophilin1 suppresses the proliferation of hematopoietic progenitor cells
Neurexophilin Dystroglycan Hematopoiesis Hematopoietic niche
2015/5/21
Neurexin I alpha (NRXN1α) and Dystroglycan (DAG1) are membrane receptors which serve as mutual ligands in the neuronal system. Neurexophilins (NXPHs) bind NRXN1α. Both NRXN1α and DAG1 were expressed i...
Regulation of mammary stem/progenitor cells by p53 and parity
Biological sciences Progenitor cells Adult stem cells Breast neoplasms Li-fraumeni syndrome Mammary gland Notch proteins Tumor suppressor protein p53
2014/12/10
Breast cancer is the most common tumor among women with inherited mutations in the p53 gene (Li-Fraumeni syndrome). The tumors represent the basal-like subtype which has been suggested to originate fr...
Prostaglandin E₂ promotes recovery of hematopoietic stem and progenitor cells after radiation exposure
hematopoiesis radiomitigation radiation
2015/5/21
The hematopoietic system is highly proliferative, making hematopoietic stem and progenitor cells (HSPC) sensitive to radiation damage. Total body irradiation and chemotherapy, as well as the risk of r...
Defining the mechanism of prostaglandin E₂-enhanced hematopoietic stem and progenitor cell homing
Prostaglandin Homing HIF1-alpha
2015/5/21
Hematopoietic stem cell (HSC) transplantation is a lifesaving therapy for a number of hematological disorders. However, to be effective, transplanted HSCs must efficiently “home” to supportive niches ...
Transcriptional Regulation of Retinal Progenitor Cells Derived from Human Induced Pluripotent Stem Cells.
Stem Cell Human iPS Differentiation Development Retina
2015/5/22
In order to develop effective cures for diseases and decipher disease pathology, the need exists to cultivate a better understanding of human development. Existing studies employ the use of animal mod...
Effects of Altering Cell Proliferation on Hematopoietic Stem and Progenitor Cell Function
hematopoietic progenitor cell cell cycle
2015/5/21
Cell cycle checkpoints guarantee movement through the cell cycle in an appropriate manner. The spindle assembly checkpoint (SAC) ensures the proper segregation of chromosomes into daughter cells durin...
Eicosanoid Regulation of Hematopoietic Stem and Progenitor Cell Function
AMD3100 G-CSF NSAID EP receptor Meloxicam
2015/5/21
dult hematopoietic stem cells (HSC) are routinely used to reconstitute hematopoiesis after myeloablation; however, transplantation efficacy and multilineage reconstitution can be limited by inadequate...