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Integrative approaches for microRNA target prediction: combining sequence information and the paired mRNA and miRNA expression profiles
miRNA target prediction expression profile integrative analysis
2016/1/25
Gene regulation is a key factor in gaining a full understanding of molecular biology. microRNA (miRNA), a novel class of non-coding RNA, has recently been found to be one crucial class of post-transac...
Imputing Missing Data for Gene Expression Arrays
Imputing Missing Data Gene Expression Arrays
2015/8/21
Here we describe three different methods for imputation.The first is based on a reduced rank SVD of the expression matrix, the second is based on K-nearest neighbor averaging, and the third is based o...
Efficient Quadratic Regularization for Expression Arrays
quadratic regularization euclidean methods SVD eigengenes
2015/8/21
Gene expression arrays typically have 50 to 100 samples and 1,000 to 20,000 variables (genes).There have been many attempts to adapt statistical models for regression and classification to these data,...