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分子发育生物学国家重点实验室黄勋研究组揭示Cds2调节线粒体磷脂含量和线粒体功能影响非酒精性肝炎NASH的快速发生（图）
分子发育生物学国家重点实验室 Cds2 黄勋 线粒体磷脂 线粒体功能 非酒精性肝炎 NASH Science Bulletin
2022/4/22
非酒精性脂肪肝(NAFLD)包括一系列肝损伤，从单纯脂肪变性到非酒精性肝炎(NASH)，后者可发展为肝硬化和肝癌(HCC)。目前NAFLD全球患病率高达25%，中国患病人口超过2.5亿，且缺乏有效治疗药物，造成重大社会负担。除非存在继发性饮食或化学肝毒性损伤，常用的遗传小鼠模型不会自发进展到肝纤维化、硬化和肝癌。因此，创造严重疾病表型（如纤维化和HCC）快速进展的遗传模型，对理解该疾病的发病致病机...
中国科学院遗传与发育生物学研究所黄勋实验室前期研究发现胞嘧啶二脂酰甘油合成酶(CDP-DAG synthase, CDS)将磷脂酸(PA)从合成甘油三酯转到合成磷脂酰肌醇，调控脂类存贮过程向胰岛素信号通路介导的细胞生长过程的转化。
探讨姜黄素是否通过抑制内质网应激（ERS）来减轻非酒精性脂肪性肝炎（NASH）大鼠肝细胞凋亡，从而发挥对肝脏的保护作用。方法：30只雄性SD大鼠随机分为正常对照组（n=10）、模型组（n=10）及姜黄素组（n=10）。模型组和姜黄素组采用高脂饮食喂养4周以建立NASH模型。继续喂养4周，姜黄素组每日给予姜黄素（200 mg/kg）灌胃，模型组与正常对照组给予等量生理盐水。4周后处死大鼠，留取血液及...
Berge极大值逆定理与Nash平衡定理
Berge极大值逆定理 Nash平衡定理 拟变分不等式 Von Neumann引理 Gale-Nikaido-Debreu引理的推广定理 伪连续
2019/4/17
本文运用Berge极大值逆定理和Nash平衡定理，通过构造适当的支付函数，直接推导出了拟变分不等式、广义变分不等式、Von Neumann引理，以及Gale-Nikaido-Debreu引理的推广定理.同时也提供了一个将上半连续凸紧值的集值映射问题转化为一个二元函数来处理的方法.这些结果和证明方法都是新的.
This paper develops bounds on the rate of decay of powers of Markov kernels
on finite state spaces. These are combined with eigenvalue estimates to give
good bounds on the rate of convergence to sta...
研究线性Markov 切换系统的随机Nash 微分博弈问题. 首先借助线性Markov 切换系统随机最优控制的相关结果, 得到了有限时域和无线时域Nash 均衡解的存在条件等价于其相应微分(代数) Riccati 方程存在解, 并给出了最优解的显式形式; 然后应用相应的微分博弈结果分析线性Markov 切换系统的混合H2/H∞ 控制问题; 最后通过数值算例验证了所提出方法的可行性.
Eciency, Fairness and Competitiveness in Nash Bargaining Games
Eciency Fairness Competitiveness Nash Bargaining Games
2012/11/30
Recently,dened the class of Linear Nash Bargaining Games (LNB) and obtained combinatorial, polynomial time algorithms for several games in this class. also denes two natural subclasses within LNB, UNB...
Equivalent Bilevel Programming Form for the Generalized Nash Equilibrium Problem
Generalized Nash equilibrium point Bilevel Programming efficient solution optimal solution
2011/11/17
Generalized Nash Equilibrium problem is widely used but hard to solve. In this paper, we transform the generalized Nash game into a special bilevel programming with one leader and multi-followers by s...
Fixed-Point Approaches to Computing Bertrand-Nash Equilibrium Prices Under Mixed Logit Demand: A Technical Framework for Analysis and Efficient Computational Methods
Mixed Logit Demand Technical Framework Analysis Efficient Computational Methods
2011/2/28
Bertrand competiton has been a prominent paradigm for the empirical study of differentiated
product markets for at least twenty years. Firms engaged in Bertrand competition maximize profits by choosi...
Nash Problem for quotient surface singularities
Nash Problem quotient surface singularities
2010/11/22
We give an affirmative answer to Nash Problem for quotient surface singularities, in particular for the icosahedral singularity $E_8$.
The Nash problem of arcs and the rational double point $\mathbf{E_6}$
The Nash problem the rational double point
2010/11/17
This paper deals with the Nash problem, which consists in proving that the number of families of arcs on a singular germ of a surface $S$ coincides with the number of irreducible components of the ex...
In the 1950s, the Nobel Prize winner John F. Nash has shown that under certain conditions, the best solution to the bargaining problem is when the product of the (increase in) utilities is the largest...
本质博弈与Nash平衡点集的本质连通区
纳什平衡点 本质博弈 本质连通区
2010/10/27
1962年吴文俊和江嘉禾对n人非合作有限博弈引进了本质平衡点和本质博弈的概念, 并证明了每一个有限博弈都能够被本质博弈任意逼近. 1963年江嘉禾对n人非合作有限博弈引进了平衡点集本质连通区的概念, 并证明了每一个有限博弈都存在至少一个平衡点集的本质连通区.这些是中国数学家对博弈论的重要贡献.
研究了多目标广义对策问题,通过Brouwer-Schauder-Tychonoff不动点定理,建立了弱Pareto-Nash均衡点的存在性结果,最后,通过一个例子,说明结果是新的、不能被已有的存在性结果所包含.