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The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
The c-MYC oncoprotein NAMPT enzyme SIRT1-inhibitor DBC1 SIRT1 deacetylase
2012/2/1
Silent information regulator 1 (SIRT1) represents an NAD+-dependent deacetylase that inhibits proapoptotic factors including p53. Here we determined whether SIRT1 is downstream of the prototypic c-MYC...
Purification of Casein Kinase II From Lung Tissue and Kinetic Evaluations With Polyamines and Myc-Oncoprotein
Casein kinase II olyamines yc ell proliferation abbreviations KII-casein kinase II myc-phosphorylated myc oncoprotein Pmax-phosphorylated max protein
2009/7/2
The overall goal of this study was to seek molecular linkages between polyamines, casein kinase II, and the myc oncoprotein by using a cell-free, highly purified enzyme kinetic analysis. Casein kinase...