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Further Studies on the Inhibitory Effect of [D-A1a6, des-Gly-NH210]LHRH Ethylamide on Spermatogenesis and Steroidogenesis in the Rat：Reversibility and Effect of Androgen Administration
antifertility spermatogenesis LHRH agonist
2009/2/18
Following the recent observation that chronic treatment with [D-Ala6, des-Gly-NH210]LHRH ethylamide, a potent LHRH agonist, leads to an almost complete degeneration of seminiferous tubules in the ra...
Multiple Forms of Rat Testicular Androgen Binding Protein：Physicochemical Properties and the Effect of Ca++
testis androgen binding protein calcium rat ABP
2009/2/18
The presence of two forms of androgen binding protein (ABP) was confirmed in rat testicular cytosol. Each was distinctly separated from the other by DEAE-cellulose chromatography and showed a sing...
Effects of short-term methylmercury exposure on metallothionein mRNA levels in the testis and epididymis of the rat
short-term methylmercury metallothionein mRNA rat
2009/2/18
Methylmercury (MeHg) is a widespread environmental contaminant that causes reproductive dysfunction in men. Metallothioneins (MTs) are low-molecular-weight proteins that can bind heavy metals and pr...
Changes in the number, proliferation rates, and bcl-2 protein immunoexpression of epithelial and periductal cells from rat epididymis during postnatal development
Basal cells cell proliferation
2009/2/18
To investigate 1) the correlation between the proliferative activity of epididymal epithelium plus myoid cells and the increase in the number of these cells and 2) the role of the basal epithelial c...
Construction and preliminary characterization of a series of mouse and rat testis cDNA libraries
Spermatogenesis Sertoli cells peritubular cells gene
2009/2/18
We have constructed a series of 23 cDNA libraries from mouse and rat testicular cells. These include libraries made from whole, intact adult testes; seminiferous tubule cells from adult testes; co...
Reproductive aging in the Brown Norway rat is characterized by accelerated germ cell apoptosis and is not altered by luteinizing hormone replacement
Brown Norway rat accelerated germ cell apoptosis luteinizing hormone replacement
2009/2/18
Reproductive aging in the male Brown Norway (BN) rat is characterized by decreased Leydig cell steroidogenesis associated with seminiferous tubule dysfunction. This could be a result of a combination ...
Temporal relation between leptin and various indices of sexual maturation in the male rat
Puberty adipose tissue testosterone gonadotropins
2009/2/18
Recent studies in humans and rhesus monkeys have suggested the possibility that the adipose tissue hormone leptin has a stimulatory and/or permissive effect on the onset of puberty in the male. We...
Cell- and region-specific localization of lysosomal and secretory proteins and endocytic receptors in epithelial cells of the cauda epididymidis and vas deferens of the adult rat
Cell- and region-specific localization secretory proteins endocytic receptors
2009/2/18
The epithelial cells lining the cauda epididymidis and vas deferens are active in endocytosis and have an abundance of lysosomes and a well-characterized secretory apparatus. However, little is kn...
Pituitary adenylate cyclase-activating polypeptide（PACAP）：effects on blood flow in the testis and caput epididymidis of the rat
blood flow testis caput epididymidis rat
2009/2/18
Pituitary adenylate cyclase-activating polypeptide (PACAP) is synthesized in developing germ cells in the testis and may act as a paracrine modulator of spermatogenesis and/or participate in tubul...
The effects of aging on the seminiferous epithelium and the blood-testis barrier of the Brown Norway rat
seminiferous epithelium blood-testis barrier Brown Norway rat
2009/2/18
Steroidogenesis and spermatogenesis decrease in aging Brown Norway rats. We therefore hypothesized that there must be accompanying morphological changes taking place in the seminiferous tubules of...
Molecular cloning and developmental expression of the major fibrous sheath protein（FS 75）of rat sperm
Molecular cloning developmental expression major fibrous sheath protein（FS 75） rat sperm
2009/2/18
The fibrous sheath (FS) is a cytoskeletal structure that encases the axoneme in the principal piece of the spermatozoon tail. In the rat, it is composed of several proteins, of which a 75-kDa polype...
Obstruction of the vas deferens alters protein secretion by the rat caput epididymidal epithelium in vivo
protein secretion rat caput epididymidal epithelium
2009/2/18
Obstruction of epididymal lumen fluid flow alters the intraluminal environment and potentially changes epididymal epithelial cell function when those functions are dependent on intraluminal regulato...
Rat seminal-vesicle secretory protein SVS II binds DNA with a preference for the 5' regulatory region of secretory protein SVS IV gene：co-isolation with components of the nuclear matrix
caltrin nuclear scaffold nuclear structure semen tissue
2009/2/18
In rats, the ventral prostate and seminal vesicles produce distinct sets of proteins whose functions and tissue-specific regulation by androgens remain unclear. We have utilized the genes encoding t...
Sodium chlorate induces undersulfation of cellular proteoglycans and increases in FSH-stimulated estradiol production in immature rat Sertoli cells
Sodium chlorate cellular proteoglycans FSH-stimulated estradiol production immature rat Sertoli cells
2009/2/18
The functional influence of cell proteoglycan (PG) undersulfation on estradiol synthesis by immature rat Sertoli cell cultures was investigated by using sodium chlorate, an inhibitor of the active s...
Adhesion and signaling proteins spatiotemporally associated with spermiation in the rat
Adhesion signaling proteins spermiation rat
2009/2/18
Spermiation, the process by which late spermatids separate from the Sertoli cell, is disrupted by a number of toxicants. In this study, we used immunohistochemistry (IHC) to identify some of the p...