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Sildenafil Improves Sleep-Related Erections in Hypogonadal Men：Evidence From a Randomized, Placebo-Controlled, Crossover Study of a Synergic Role for Both Testosterone and Sildenafil on Penile Erections
Nitric oxide pathway androgen hypogonadism penile rigidity and tumescence nocturnal erection
2008/12/23
To study the effects of sildenafil on human sleep-related erections according to the state of androgenization, we evaluated the effects of sildenafil on sleep-related erections in hypogonadal men ...
Testosterone Replacement Therapy for Male Aging：ASA Position Statement
Testosterone Replacement Therapy Male Aging ASA Position Statement
2008/12/23
The American Society of Andrology suggests that testosterone replacement therapy in aging men is indicated when both clinical symptoms and signs suggestive of androgen deficiency and decreased testo...
Testosterone Replacement Therapy for Older Men
Testosterone Replacement Therapy Older Men
2008/12/23
The interest in possible medical interventions to promote healthy aging has been recently increasing, as the absolute number and the proportion of men over 60 years of age is expected to increase duri...
Oral Testosterone in Oil：Pharmacokinetic Effects of 5 Reduction by Finasteride or Dutasteride and Food Intake in Men
Androgen hypogonadism metabolism acyline
2008/12/23
Oral administration of 400 mg of testosterone (T) in oil, when combined with the 5 reductase inhibitor dutasteride (D), elevates serum T in medically castrated men to the normal range. In this study...
Changes in Testosterone and Dihydrotestosterone Levels in Male Rat Accessory Sex Organs, Serum, and Seminal Fluid After Castration：Establishment of a New Highly Sensitive Simultaneous Androgen Measurement Method
LC-MS/MS hormone prostate seminal vesicles
2008/12/23
It is known that abnormal androgen dynamics in the tissues is a cause of androgen-dependent disorders. Investigation of tissue androgen levels could provide a clue to the elucidation of disorders....
by Adult Rat Sertoli Cells：Effects of Testosterone Withdrawal and Replacement
Estradiol androgen testis protease inhibitor
2008/12/23
Protein C inhibitor (PCI), a member of the plasma serine protease inhibitor family, has been reported to be abundantly expressed in the seminal vesicles and testes. In this study, we examine the l...
Response: Responsiveness to Tamoxifen Citrate and Testosterone Undecanoate Is Independent of the Severity of Idiopathic Oligozoospermia
Tamoxifen Citrate Testosterone Undecanoate Idiopathic Oligozoospermia
2008/12/23
My confusion originates from the following wording: "total sperm count x 106/mL" present in the abstract and in table 1, page 916, of the Adamopoulos article (Adamopoulos et al, 2003). In this regar...
Responsiveness to Tamoxifen Citrate and Testosterone Undecanoate Is Independent of the Severity of Idiopathic Oligozoospermia
Tamoxifen Citrate Testosterone Undecanoate Severity Idiopathic Oligozoospermia
2008/12/23
In their recent article, "Cinnoxicam and L-Carnitine/Acetyl-L-Carnitine Treatment for Idiopathic and Varicocele-Associated Oligoasthenospermia," Cavallini et al (J Androl. 2004;761-770) made a refer...
Testosterone Administration Suppresses Adiponectin Levels in Men
Androgen hypogonadal leptin
2008/12/22
Testosterone (T) administration to men increases lean body mass and decreases fat mass. Adiponectin is produced by adipocytes and is thought to influence insulin sensitivity. In this study, we sou...
Temporal Relationships Among Testosterone Production, Steroidogenic Acute Regulatory Protein (StAR), and P450 Side-Chain Cleavage Enzyme（P450scc）During Leydig Cell Aging
Leydig cell cyclic AMP steroidogenesis Brown Norway rat
2008/12/22
Previous studies have shown that the capacity of Leydig cells from aged (21-24-month-old) Brown Norway rats to produce testosterone is reduced from young (4-month-old) levels, and that this is cor...
Rapid Glucocorticoid Mediation of Suppressed Testosterone Biosynthesis in Male Mice Subjected to Immobilization Stress
Leydig cell cyclic AMP glucocorticoid receptor
2008/12/22
Physical and psychosocial stress challenge homeostasis, increasing glucocorticoid secretion (in rodents, corticosterone [CORT]) while decreasing testosterone (T) levels. The dynamics of stress-induc...
Restorative Increases in Serum Testosterone Levels Are Significantly Correlated to Improvements in Sexual Functioning
Randomized controlled trial androgen gel hypogonadism sexual dysfunction
2008/12/22
It is recognized that testosterone (T) levels decrease in men with age, as does sexual function. We hypothesize that T supplementation in hypogonadal men with sexual dysfunction will restore certain...
Intratesticular Testosterone Concentrations Comparable With Serum Levels Are Not Sufficient to Maintain Normal Sperm Production in Men Receiving a Hormonal Contraceptive Regimen
Intratesticular androgens spermatogenesis gonadotropins progestogens
2008/12/22
Intratesticular testosterone (ITT) is thought to play a key role in the control of spermatogenesis in man but is rarely measured. The purposes of this study were 1) to examine the relationship betwe...
Male Hormonal Contraception: Suppression of Spermatogenesis by Injectable Testosterone Undecanoate Alone or With Levonorgestrel Implants in Chinese Men
Androgens contraceptive progestins family planning
2008/12/22
Monthly injections of testosterone undecanoate (TU) act as a male contraceptive by reversibly suppressing spermatogenesis to azoospermia or severe oligoazoospermia in 95% of Chinese men. In 5% of ...
Flutamide Administration at 500 mg Daily Has Similar Effects on Serum Testosterone to 750 mg Daily
Prostate neoplasm antiandrogen hormone PSA androgen deprivation
2008/12/22
A prior comparison of 750 mg flutamide daily to 500 mg daily with an LHRH analog or orchiectomy showed no difference in effect on prostate specific antigen (PSA). However, any difference was likely ...