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Hypoprolactinemia does not prevent restoration of normal spermatogenesis in gonadotropin-suppressed, testosterone-replaced rats
Spermatogenesis testosterone prolactin gonadotropin GnRH immunization
2009/2/16
We have previously shown that suppression of gonadotropins and spermatogenesis can be produced in rats by immunization against gonadotropin releasing hormone (GnRH). Administration of testosterone (...
Testosterone and spermatogenesis: evidence that androgens regulate cellular secretory mechanisms in stage VI-VIII seminiferous tubules from adult rats
Testosterone spermatogenesis androgens regulate cellular secretory mechanisms adult rats
2009/2/13
The aim of this study was to investigate the effect of testosterone manipulation on the quantitative synthesis and secretion of a number of specific proteins produced by seminiferous tubules (ST) ...
Intratesticular testosterone concentration following intratunical administration in the hypogonadal animal
Testosterone tunica vaginalis hypogonadism infertility
2009/2/13
The serum and intratesticular testosterone concentration (ITC) after testosterone administration in the tunica vaginalis (TV) sac compared to parenteral administration was studied in 20 dogs that were...
Age-related decreased Leydig cell testosterone production in the brown Norway rat
Aging Leydig cell testosterone LII Brown Norway
2009/2/13
Previous studies have demonstrated that Leydig cell testosterone production diminishes with age in Brown Norway rats. The objective of the studies presented herein was to test the following possible...
Testosterone regulation of proto-oncogene c-myc expression in primary Sertoli cell cultures from prepubertal rats
Cyclohexlmlde testis actinomycin-D
2009/2/13
The expression of c-myc has been associated with cell proliferation through changes of nuclear function. To evaluate the possibility that the proto-oncogene c-myc plays a role in testosterone-depend...
Changes in the endocrinological milieu after clomiphene citrate treatment for oligozoospermia：the clinical significance of the estradiol/testosterone ratio as a prognostic value
E5/T ratio clomiphene citrate male infertility
2009/2/12
We have already reported that the rate of increase in the estradiol/testosterone ratio (E2/T ratio) following human chorionic gonadotropin (hCG) injection has prognostic value in the treatment of olig...
Follicle-stimulating hormone（FSH）escape during chronic gonadotropin-releasing hormone（GnRH）agonist and testosterone treatment
GnRH agonist FSH male contraception spermatogenesis
2009/2/12
Observations that serum follicle-stimulating hormone (FSH) levels begin to rise after initial suppression during chronic gonadotropin-releasing hormone (GnRH) agonist treatment of men with prostat...
FSH is produced by GnRH-deficient men and is suppressed by testosterone
FSH GnRH-deficient men testosterone
2009/2/12
Because there is an unexpected action of testosterone (T) to increase follicle-stimulating hormone (FSH) production in the absence of gonadotropin-releasing hormone (GnRH) in the rat, the effects of T...
A ten-year safety study of the oral androgen testosterone undecanoate
safety study oral androgen testosterone undecanoate
2009/2/12
Testosterone undecanoate (Andriol) is an oral androgen that provides the hypogonadal patient with the unmodified testosterone molecule. It was introduced in the mid-1970s. This is a report on the safe...
A ten-year safety study of the oral androgen testosterone undecanoate
Drug safety liver functions gynecomastia benign
2009/2/12
Testosterone undecanoate (Andriol) is an oral androgen that provides the hypogonadal patient with the unmodified testosterone molecule. It was introduced in the mid-1970s. This is a report on the ...
Comparative effects of two different delivery systems on gonadotropin-releasing hormone（GnRH） antagonist-induced suppression of gonadotropins and testosterone in man
GnRH antagonists luteinizing hormone (LH)
2009/2/12
The Nal-Glu gonadotropin-releasing hormone (GnRH) antagonist, when given in daily subcutaneous (SC) doses of 5 mg or higher, maximally suppresses serum luteinizing hormone (LH) and follicle-stimul...
The direct pituitary effect of testosterone to inhibit gonadotropin secretion in men is partially mediated by aromatization to estradiol
LH FSH bioactivity androgens estrogens DHT
2009/2/12
In men, administration of exogenous testosterone (T) exerts direct negative feedback effects at the pituitary as well as at the hypothalamic level. This study was undertaken to determine whether T i...
Testosterone feedback on gonadotropin secretion and gene expression in transgenic mice expressing human growth hormone gene
Luteinizing hormone follicle-stimulating hormone
2009/2/12
To determine the effects of testosterone on the regulation of gonadotropins in metallothionein-1/human growth hormone (MT/hGH) transgenic mice, basal and gonadotropin-releasing hormone (GnRH)-stim...
Pharmacokinetics and pharmacodynamics of a parenteral testosterone microsphere formulation in the male rat. Demonstration of dose dependence and controlled release
Testosterone microsphere formulation androgen delivery methods testosterone effects on LH, FSH, and accessory sex organs rat
2009/2/11
This study examined the pharmacokinetics (the time course and pattern of testosterone release) and pharmacodynamics (effects on accessory sex organ weights, and serum LH and FSH levels) of a biode...
Dose-response effects of gonadotropin-releasing hormone on plasma concentrations of gonadotropins and testosterone in fertile and subfertile stallions
gonadotropin-releasing hormone luteinizing hormone follicle-stimulating hormone testosterone horse fertility
2009/2/11
Five fertile and five subfertile stallions were treated with a single intravenous injection of saline the first week followed by a single intravenous injection of varying doses of gonadotropin-rel...