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Spermatic granulomata are experimentally induced in epididymides of mice receiving high-dose testosterone implants. I. A light-microscopical study
Spermatic granulomata high-dose testosterone
2009/2/18
It is known that a spermatic granuloma is induced by the inflammatory reaction following leakage of spermatozoa outside the germ cell ducts and is the main clinical complication of vasectomy. In t...
A lower dosage levonorgestrel and testosterone combination effectively suppresses spermatogenesis and circulating gonadotropin levels with fewer metabolic effects than higher dosage combinations
testosterone combination circulating gonadotropin levels metabolic effects
2009/2/18
Studies using exogenous high-dosage testosterone (T) or a combination regimen of physiologic T plus high-dosage levonorgestrel (LNG) administration in normal men have shown that oligoazoospermia (...
Follicle-stimulating hormone and testosterone stimulation of immature and mature Sertoli cells in vitro：inhibin and N-cadherin levels and round spermatid binding
Follicle-stimulating hormone testosterone stimulation immature mature Sertoli cells
2009/2/18
The in vitro response of Sertoli cells isolated from adult rat testes to testosterone (T) and follicle-stimulating hormone (FSH) treatment was investigated. Sertoli cells from >70-day-old Sprague-...
Testosterone-dependent restoration of spermatogenesis in adult rats is impaired by a 5alpha-reductase inhibitor
Testosterone-dependent restoration spermatogenesis adult rats 5alpha-reductase inhibitor
2009/2/18
Germ cell development (spermiogenesis in particular) in the adult rat is known to be testosterone dependent. Recently we proposed a role for the 5alpha reduction of testosterone to dihydrotestostero...
A pharmacokinetic study of injectable testosterone undecanoate in hypogonadal men
Testosterone LH FSH estrogen SHBG
2009/2/18
Testosterone undecanoate (TU) provides testosterone (T) replacement for hypogonadal men when administered orally but requires multiple doses per day and produces widely variable serum T levels. We i...
Does age-associated reduced Leydig cell testosterone production in Brown Norway rats result from under-stimulation by luteinizing hormone?
Aging testis steroids rat
2009/2/18
Previous studies have shown that reductions in Leydig cell testosterone production occur with aging in the Brown Norway rat. The recent observation that changes in luteinizing hormone (LH) pulse i...
Hormonal regulation of spermatogenesis in the hypophysectomized rat: quantitation of germ-cell population and effect of elimination of residual testosterone after long-term hypophysectomy
Testis germ cells androgen morphometry
2009/2/17
Spermatogenesis continues after long-term hypophysectomy (Hx), but massive cell degeneration prevents seminiferous tubules from attaining the full complement of cells. One objective of this study ...
Effect of chorionic gonadotropin and flutamide on Leydig cell and macrophage populations in the testosterone-estradiol-implanted adult rat
chorionic gonadotropin Leydig cell macrophage populations testosterone-estradiol-implanted adult rat
2009/2/17
The objective of this study was to investigate the role of androgens and nonandrogenic Leydig cell products in maintaining Leydig cell and macrophage numbers in the testis of the adult rat. Adult ...
Testosterone decreases 3beta-hydroxysteroid dehydrogenase-isomerase messenger ribonucleic acid in cultured mouse Leydig cells by a strain-specific mechanism
Steroidogenesis testis inbred mice androgen
2009/2/17
We previously reported a strain-related difference in basal 3beta-hydroxysteroid dehydrogenase-isomerase (3betaHSD) activity in response to testosterone in cultured Leydig cells. The data suggested ...
Relationship between sleep-related erections and testosterone levels in men
Testosterone range testosterone threshold hypogonadism night erections
2009/2/17
In order to identify a possible threshold for a serum testosterone level below which sleep-related erections are impaired and to compare this threshold with the normal laboratory range of testostero...
The number and magnitude of studies involving testosterone-supplementation therapy in older men are limited. In addition, many studies to date have not been blinded or controlled, were reported in...
Comparison of the response of rat testis and accessory sex organs to treatment with testosterone and the synthetic androgen methyltrienolone（R1881）
Androgens spermatogenesis testis prostate
2009/2/17
We have studied the ability of the synthetic androgen methyltrienolone (R1881) to maintain testis and accessory organ weights, as compared to the effect of testosterone propionate (TP). In contrast ...
Purification and characterization of a lipophilic factor from testicular macrophages that stimulates testosterone production by Leydig cells
Testis macrophage Leydig cell
2009/2/16
Testicular macrophages have been shown to secrete a factor that stimulates testosterone production by Leydig cells. The purpose of this investigation was to purify and characterize this factor. M...
The effects of recombinant FSH on testosterone-induced spermatogenesis in gonadotrophin-deficient（hpg）mice
Seminiferous tubule testis Sertoli cells FSH testosterone
2009/2/16
In order to clarify the mechanism of synergism between follicle-stimulatory hormone(FSH) and testosterone (T) in the hormonal regulation of spermatogenesis, we studied the effects of recombinant h...
Testosterone autoregulation of its biosynthesis in the rat testis：inhibition of 17 alpha-hydroxylase activity
1 7a-Hydroxylase testosterone autoregulation rat
2009/2/16
Using the in vitro perfused rat testis, the effects of testosterone (T) on its own biosynthesis, and in particular on the inhibition of specific steroidogenic step(s) in the biosynthetic pathway fro...