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The Effect of Neuronal Nitric Oxide Synthase Inhibitor 7-Nitroindazole on the Cell Death Induced by Zinc Administration in the Brain of Rats
Zinc cell death hippocampus 7-nitroindazole stereology rat
2009/5/20
Aim: To evaluate the effect of the neuronal nitric oxide synthase (nNOS) inhibitor 7-nitroindazole (7-NI) on hippocampal cell loss induced by zinc hemisulfate salt (ZnSO4·7H2O) treatment. Materials an...
Zinc contribution to the regulation of glucose disposal, lipid metabolism and striated muscle contractions
zinc homeostasis zinc deficiency insulin sensitivity lipids striated muscle
2009/4/2
Zinc is the second, after iron, most abundant trace metal in the human body. In living systems zinc performs three categories of functions- catalytic, structural and regulatory. Zinc homeostasis is ...
Comparative study of insulin-mimetic activity of vanadium and zinc complexes
vanadyl(IV) zinc(II) insulin-mimetic effect type 1 diabetes mellitus
2009/4/1
In recent years, some metal ions and their complexes have been found to treat diabetes mellitus (DM) in not only experimental animals but also humans. Among them, vanadyl(IV) and zinc(II) ions as well...
Effect of zinc on hepatoprotectivity of α1-acid glycoprotein
αl-acid glycoprotein zinc hepatoprotection thermal property
2009/4/1
αl-Acid glycoprotein (AGP) prevented primary hepatocytes from undergoing cell death induced by the chemical toxin, bromobenzene at range from 0.1 to 0.2 mg/ml. Addition of zinc (0.2 mM) to medium cont...
Effects of gadolinium and other metal on the neurotoxicity of immortalized hypothalamic neurons induced by zinc
zinc GT1-7 gadolinium aluminum apoptosis
2009/4/1
Zinc is an essential trace element and crucial for numerous biological functions. In contrast, excessive zinc in the synapses plays central roles in the neurodegenerative processes following brain inj...
Insulinomimetic activity of zinc（II）complexes with halogenated picolinic acids
diabetes insulinomimetic activity zinc(II) complex picolinic acid derivatives
2009/4/1
We prepared six new zinc(II) complexes of halogenated picolinic acids with a Zn(N2O2) coordination mode and evaluated for their insulinomimetic activities by in vitro study. By introducing an electron...
Modulation of cytokine expression by zinc and metallothionein
zinc metallothionein cytokine IL-1 IL-6 M-CSF TNF
2009/4/1
A metal chelator diethylenetriaminepentaacetic acid (DTPA) has been reported to inhibits replication of human cytomegalovirus (hCMV). In the investigation of the mechanism of DTPA-induced antiviral ef...
Protein Utilization in Rats during Early Stages of Zinc Deficiency
protein utilization zinc deficiency tube feeding rats
2009/4/1
The effects of zinc deficiency on protein utilization in rats during gastric tube feeding were investigated. Rats fed a zinc-deficient diet ad libitum ceased growing on the 4th day. Thereafter, rats w...
Role of Zinc in Regulation of Osteoclastogenesis
zinc osteoclastogenesis bone resorption osteoporosis
2009/4/1
Zinc administration prevents bone loss in rats with ovariectomy, skeletal unloading, hydrocortisone treatment, adjuvant arthritics and diabetic condition in rats. Zinc has been shown to play a role ...
Studies on Anti-obesity Effects of Zinc (II) Complex On The Rats Fed High-fat Diet
Zn(II) complex with ascorbic acid or carnitine anti-obesity high fat diet blood fluidity
2009/4/1
The objective of this study is to investigate the effects of zinc(II)molecular complex with ascorbic acid (Zn(VC)2), carnitine (Zn(Car)2Cl2), and glutamine (Zn(Gln)2) on obesity and blood fluidity. We...
Antimicrobial Effects of Zinc Oxide in an Orthodontic Bonding Agent
Zinc oxide Antimicrobial effects Decalcification Bond strength
2010/3/5
Objective: To test the null hypothesis that the addition of zinc oxide (ZnO) has no effect on the antimicrobial benefits and shear bond strength of a light-cured resin-modified glass ionomer.
Mater...
Differences in the Serum Zinc Level of Rural and Urban Residents in a City in the Central Part of Japan, Examined at Annual Community-Wide Health Examination
serum zinc concentration zinc deficiency public health eating habit change
2009/3/23
Zinc deficiency is becoming a subject of greater clinical interest than ever before, especially in an aging society. In 2002, many zinc deficient patients visited our clinic. To understand why so many...
Inhibitory Effect of Oxovanadium（IV）, Copper（II）, and Zinc（II）Ions on the Activity of an Alpha-glucosidase from a Saccharomyces sp.
Alpha-glucosidase inhibition Anti-diabetic effect STZ-mice Oral carbohydrate tolerance test Metal ions
2009/3/23
We investigated the in vitro and in vivo effects of metal ions on the activity of an alpha-glucosidase (Saccharomyces sp.). CuSO4, ZnSO4, and VOSO4 significantly inhibited the alpha-glucosidase activi...
Inhibitory Modulation of Glutamatergic Neuron Activity by Zinc in the Hippocampus
zinc glutamate mossy fiber hippocampus calcium exocytosis synaptic plasticity
2009/3/23
Zinc exists in high densities in the giant boutons of hippocampal mossy fibers. Zinc decreases extracellular glutamate concentration in the hippocampus, suggesting inhibitory modulation of glutamaterg...
Normalizing Effect of Zinc（II）Complex with 6-Ethoxy Picolinic Acid on Blood Glucose Levels in KK-Ay Mice
diabetes Zn(II) complex KK-Ay blood glucose level
2009/3/23
We examined normalizing effect for blood glucose levels of zinc(II) complex with 6-ethoxy picolinic acid (Zn(6-EtOpa)2) on KK-Ay mice which used in this study as the model animals of type 2 diabetes, ...