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HIV-1整合酶抑制剂的研究进展
HIV-1 整合酶 抑制剂
2009/10/15
本文介绍了目前正处于临床试验的人类免疫缺陷病毒-1(HIV-1)整合酶抑制剂S-1360和L-870810；另外，主要叙述了近年来发展比较迅速的三大类HIV-1整合酶抑制剂，即一般含芳环化合物、寡聚核苷酸和寡聚肽的研究进展。
《科学》：HIV病毒1亿年前就开始摧毁哺乳动物免疫系统（图）
HIV病毒 哺乳动物免疫系统
2009/10/9
据《科学日报》2009年9月28日报道，科学家们发现，导致HIV病毒的逆转录病毒早在1亿年前就已经对哺乳动物的免疫系统产生影响，这比其以前的观点，提前了近8500万年。
研究带有不同变异位点的人免疫缺陷病毒1型（HIV1）vpr基因对感染细胞周期和凋亡的影响，以及其致细胞周期变化和致细胞凋亡的机制间的可能关系。方法以14个带有HIV1 vpr基因片段的pcDNA3.1（+）真核表达载体构建重组质粒，将其转染Hela细胞，并设立保守株vpr基因转染细胞、突变株vprFS基因转染细胞、空载体转染细胞和未转染细胞作为对照，经逆转录多聚酶链式反应（RTPCR）检测...
The Effectiveness of HIV⁄AIDS awareness intervention in a rural area of Cambodia: illiteracy, mobility, sexual behavior, and HIV⁄AIDS
HIV Cambodia awareness intervention
2010/12/10
To convey HIV⁄AIDS-related knowledge to people in rural Cambodia, we conducted an HIV⁄AIDS awareness intervention program and investigated its effectiveness, participants’ sexual behavior,...
Prevalence of HIV and Hepatitis C Virus Infections and Related Behavioral Determinants among Injecting Drug Users of Drop-in Centers in Iran
DICs IDUs Prevalence HIV HCV High-risk behaviors Iran
2015/9/18
Background: Drop-in centers (DICs) are set up to reduce the harms of high-risk behaviors in high-risk groups especially in injecting drug users (IDUs). This study aimed to determine the prevalence of ...
The Prevalence of M. Tuberculosis Infection and Disease in HIV Positive Individuals in Shiraz, Southern Iran
HIV M. tuberculosis Prevalence Coinfection Southern Iran
2015/9/18
Background: The emergence of HIV infection and its close association with TB poses an even greater challenge to the health systems and when co-infection is present, it is the most potent risk factor f...
Association between PPD and QuantiFERON Gold TB Test in TB Infection and Disease among HIV-Infected Individuals in Southern Iran
HIV Tuberculosis QuantiFERON Gold TB test PPD
2015/9/18
Background: Tuberculosis is one of the most common diseases among HIV-infected patients. A person with a positive tuberculin skin test (TST) acquiring HIV infection has a 3-13% annual risk of developi...
A Model for Involving Youth in Health Planning：HIV Prevention in Pennsylvania
Health Planning Pennsylvania HIV Prevention
2009/9/17
Despite major advances in the treatment of HIV and AIDS, continued transmission of HIV remains a major public health problem. Declines in AIDS incidence during the 1990s were not accompanied by compar...
HIV Counseling and Testing：Women's Experiences And the Perceived Role of Testing As a Prevention Strategy
HIV Counseling Prevention Strategy Women's Experiences
2009/9/17
CONTEXT: It is unclear why women decide to undergo testing for HIV, and how positive and negative test results impact their sexual behavior.
METHODS: A sample of 360 family planning clinic clients...
Context: HIV-positive men and women may have fertility desires and may intend to have children. The extent of these desires and intentions and how they may vary by individuals' social and demographic ...
Risk Factors for HIV and Other Sexually Transmitted Diseases Among Adolescents in St. Petersburg, Russia
Sexually Transmitted Diseases Russia Adolescents
2009/9/16
Context: Over the past several years, there have been sharp increases in the prevalence of HIV and other sexually transmitted diseases (STDs) among young people in Russia. Very little is known about R...
Condom Use and HIV Risk Behaviors Among U.S. Adults：Data from a National Survey
Condom Use U.S. Adults HIV Risk
2009/9/15
Context: How much condom use among U.S. adults varies by type of partner or by risk behavior is unclear. Knowledge of such differentials would aid in evaluating the progress being made toward goals fo...
脐血和外周血单个核细胞培养上清影响HIV-1感染的体外实验研究
胎血 单核细胞 细胞因子类 HIV-1
2009/8/24
目的：体外研究脐血和外周血单个核细胞（CBMC和PBMC）培养上清对HIV-1感染的影响，为发现抗HIV-1的可溶性因子奠定基础。 方法： PHA刺激CBMC和PBMC后5 h和12 h收集上清，加入荧光标记的HIV-1ⅢB/H9和MT-2细胞培养体系中，2 h后在倒置荧光显微镜下观察其对细胞融合的影响；用Luminex 100TM分析仪检测收集上清中细胞因子含量。 结果： PHA刺激CBMC和P...
HBV与HIV重叠感染及其影响
乙肝病毒 人类免疫缺陷病毒 超感染 共感染
2009/8/17
我国作为乙型肝炎大国, 面临乙肝的严重威胁, 而HIV和HBV的传播途径相似, HIV/HBV重叠感染可加速HIV感染者的病程并增加其死亡率, 同时也影响到HBV感染的自然史. 现就近年的相关文献作简要回顾, 以进一步提高临床工作者的认识和警惕性.
《自然》：HIV病毒基因组结构被完全破解
HIV病毒 基因组结构
2009/8/7
据英国广播公司BBC报道，美国科学家们宣布HIV病毒的基因组结构已经被完全破解。这项研究的成果已经被刊登在《自然》杂志上，供人们进一步审视潜藏在HIV病毒内部的信息。