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EGFR expression and activation in bovine cumulus cells and EGFR intramolecular regulation through interactions between tyrosines
Epidermal growth factor receptor the process of cell the cell cycle cell migration cell metabolism cell proliferation oocytes and embryo development activation of cumulus cells
2014/12/11
The epidermal growth factor receptor (EGFR) plays important roles in the control of many fundamental cellular processes including cell cycle, cell migration, cell metabolism and survival, cell prolife...
Contribution of non-centrosomal microtubules to mitotic spindle assembly in mammalian cells
Mammalian cells bipolar spindle and chromosome microtubule mammals bipolar spindles
2014/12/11
In mammalian cells, the formation of a bipolar spindle is an essential process as any mistake in the segregation of chromosomes can result in aneuploidy, an outcome that can be detrimental to the orga...
Organization and dynamics of actin and myosin during cytokinesis in mammalian epithelial cells
Cytokinesis separation of cell division biological process actin polymer structure myosin
2014/12/11
Cytokinesis, the process of physically separating cells for division, requires the precise orchestration of numerous physical, mechanical, chemical and biological processes. For these processes to fun...
Organization and maintenance of the motor nerve terminal: Roles for presynaptic actin and perisynaptic Schwann cells
Frog neuromuscular actin nerve terminals protein cell skeleton
2014/12/11
At the adult frog neuromuscular junctions (Rana pipien and Rana catesbiana), F-actin microfilaments are enriched in the nonrelease domains of nerve terminals, outside the vesicle-rich release sites. T...
WC1 mediates T cell activation and is required for the response of bovine gammadelta T cells to Leptospira antigen
Biological sciences T cell activation Leptospira
2014/12/11
Workshop cluster 1 (WC1) molecules are exclusively expressed on the surface of γδ T cells. They belong to the scavenger receptor cysteine-rich (SRCR) superfamily and are encoded by a multiple-gene fam...
Regulation of mammary stem/progenitor cells by p53 and parity
Biological sciences Progenitor cells Adult stem cells Breast neoplasms Li-fraumeni syndrome Mammary gland Notch proteins Tumor suppressor protein p53
2014/12/10
Breast cancer is the most common tumor among women with inherited mutations in the p53 gene (Li-Fraumeni syndrome). The tumors represent the basal-like subtype which has been suggested to originate fr...
Regulation of the Hypothalamic Precursor Cells by HH/GLI Signaling in Post-Embryonic Zebrafish
Biological sciences Health and environmental sciences Heat-shock Hedgehog signaling Hypothalamus Neurogenesis Transgenic
2014/12/10
The major goals of my research were to characterize the hypothalamic neural progenitors and to understand how Hh/Gli signaling plays a role in regulating cell proliferation in the hypothalamic neuroge...
WC1 Functions as a Co-Receptor and A Pattern Recognition Receptor In Bovine Gamma delta T Cells
Health and environmental sciences Endocytosis Gamma delta t cells Receptor-ligand interactions Wc1 Pattern recognition receptors
2014/12/10
WC1 proteins specifically expressed on the surface of γδ T cells are members of group B Scavenger Receptor Cysteine Rich (SRCR) superfamily, in which receptors contain several SRCR domains in the extr...
NON-CANONICAL NOTCH SIGNALING REGULATES ACTIVATION AND DIFFERENTIATION OF PERIPHERAL CD4+ T CELLS
Notch non-canonical T cell NF-kB mTOR activation differentiation cross-talk
2014/12/10
Cleavage of the Notch receptor via a γ-secretase, results in the release of the active intra-cellular domain of Notch that migrates to the nucleus and interacts with RBP-JΚ, resulting in the activatio...
An inside job: UC-designed nanoparticles infiltrate, kill cancer cells from within（图）
cancer cells infiltrate
2014/12/1
Conventional treatment seeks to eradicate cancer cells by drugs and therapy delivered from outside the cell, which may also affect (and potentially harm) nearby normal cells.
HOUSTON — (Oct. 31, 2014) — In the first study of its kind, Rice University researchers have mapped how information flows through the genetic circuits that cause cancer cells to become metastatic. The...
HOUSTON — (Oct. 31, 2014) — In the first study of its kind, Rice University researchers have mapped how information flows through the genetic circuits that cause cancer cells to become metastatic. The...
ScientistshavedescribedawaytoconverthumanskincellsdirectlyintoaspecifictypeofbraincellaffectedbyHuntington’sdisease,anultimatelyfatalneurodegenerativedisorder.Unlikeothertechniquesthatturnonecelltypei...
Scientists have described a way to convert human skin cells directly into a specific type of brain cell affected by Huntington’s disease, an ultimately fatal neurodegenerative disorder. Unlike other t...
By sorting human fat tissue cells by their expression of a certain gene, Brown University scientists were able to retrieve a high yield of cells that showed an especially strong propensity to make bon...