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Allergic Asthma: What Have We Learned from the Mouse Model?
allergy asthma interleukin-13 mast cell mouse T lymphocyte
2010/11/19
Despite advances and introduction of new and effective anti-asthma therapies, including inhaled corticosteroids and leukotriene modifiers, the mortality and morbidity of asthma is still a worldwide co...
IL-13/IL-13 Receptor Interaction, an Emerging Therapeutic Target in Allergic Disease
allergy antagonist asthma drug design interleukin-13 receptor
2010/11/19
Interleukin (IL)-13 is a Th-2 cytokine, known to be involved in allergic diseases. Although IL-13 and another Th-2 cytokine, IL-4, share receptors and signal pathways, having similar biological proper...
Increased Levels of CTGF mRNA Expression in a Murine Model of Allergic Airway Inflammation
asthma collagen remodeling subepithelial fibrosis TGF-β
2010/11/19
Numbers of eosinophils and TGF-β1 concentration increased markedly in BALF on the 7th day and 14th day after inhalation challenge with OVA. Hydroxyproline content in lung tissue increased significantl...
Measurement of Indoor Airborne Mite Allergens
airborne allergen allergen avoidance bedding house dust mite
2010/11/19
To evaluate the extent of exposure to airborne mite allergens, we measured major mite allergens in indoor environments with an immunoassay using allergen-specific antibodies. The levels of mite allerg...
CpG Oligodeoxynucleotides as a Future Vaccine for Allergic Diseases
antigen-specific bronchial asthma dendritic cell Th1/Th2 cell
2010/11/19
An astounding feature of the DNA sequences termed CpG motifs is the induction of immune and inflammatory responses in a senseless manner. CpG motifs exist abundantly in microbes and evoke innate immun...
The High Affinity IgE Receptor (FcεRI) as a Target for Anti-allergic Agents
FcεRI gene expression humanized anti-FcεRI α chain antibody IgE soluble α
2010/11/19
Prevention of the effector cell activation via high affinity IgE receptor (FcεRI) is thought to be a straightforward strategy for suppressing the allergic reaction. Among the numerous methods to preve...
Serum levels of soluble CD14 in allergic inflammation
asthma atopic dermatitis CD14 inflammation macrophage monocyte
2010/11/29
Monocytes/macrophages have recently been shown to play a significant role in the pathogenesis of allergic diseases. As the level of soluble CD14 (sCD14) in serum is considered a marker of monocyte/mac...
Stinging insect allergy
clinical reactions diagnosis immunotherapy natural history venom allergy
2010/11/29
Stinging insect allergy is a relatively common medical problem, responsible for an estimated 40 fatalities per year in the USA and considerable anxiety and lifestyle modification. There are no criteri...