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以北京地区为研究区域, 利用四级逸度模型方法建立了北京地区HCHs的归宿模型. 模型模拟了1952~2003年间每年的HCHs迁移通量和残留量, 对计算所得各环境相中HCHs浓度值与各时期实测浓度进行的验证表明二者吻合较好. 1952~1983年间, 平均每年由农业施用进入研究区域环境中的HCHs约为130 t, 随气平流输入量620 t, 二者占总输入量的90%; 界面间迁移过程中, 气-土沉降...
粉末直接压片工艺:制药工业整体发展的助推剂
直接压片 流动性 可压性 复合辅料
2009/3/25
片剂具有工艺简单、服用方便、剂量准确以及稳定性好等优点,因而一直是临床最常用的剂型。与传统的湿法制粒工艺相比,直接压片工艺是一种简单、经济的新型片剂制造方法,正日益引起人们的关注。该工艺在体现出简单经济的同时有自身的技术特征需要重点理解和掌握,如粉末的流动性、可压性、稀释潜力、含量均一及润滑敏感性等。目前片剂生产正向直接压片和高速生产转变,要求辅料工业不断推出新型辅料。预混复合型辅料由于能满足现代...
The drug release from a coated planar matrix with a sub-saturation loading in the core
coated planar matrix controlled release diffusion
2009/3/25
The drug release from a coated planar matrix with a sub-saturation loading in the core.
To achieve higher antibiotic streptolydigin productivity through metabolic regulation, propionate was fed during the fermentation of Streptomyces lydicus AS 4.2501. The effects of propionate feeding o...
采用CO2吸附剂吸附强化的甲烷水蒸汽反应制药厂氢过程特点
二氧化碳 吸附剂 氢气 生产工艺
2009/3/13
The objective of the present study is to characterize the production of hydrogen with a sorptionenhanced steam-methane reaction process using Ca(OH)2 as the CO2 adsorbent. Theoretical equilibrium com...
超临界流体色谱手性分离布洛芬
超临界液体色谱 手性分离 布洛芬
2009/3/13
The separation method using chiral stationary phase (CSP) for the preparation of enantioselective compound was widely used. In this work, supercritical fluid chromatography(SFC) was proposed to resolv...
氮源对利迪链菌素生产及相关次级代谢物分布的影响
次级代谢物 氮源对利迪链菌素
2009/3/11
The effects of nitrogen sources on streptolydigin production and distribution of secondary metabolites were investigated for flask cultured S. lydicus AS 4.2501. When peptone, asparamide, and glutam...
海澡酸钙胶囊化重组E.coli BL21(DE3)生产靛蓝
calcium-alginate gel gene engineering strain immobilized cells
2009/3/10
The ability of catalyzing indole into indigo of gene engineering strain expressing P450 BM3 immobilized by entrapment in calcium-alginate gel capsules was examined, and various characteristics of immo...
航天诱变提高Streptomyces gilvosporeus的那他霉素产量
space-flight mutation Streptomyces gilvosporeus natamycin rational screening
2009/3/10
Mutants of the strain producing natamycin, Streptomyces gilvosporeus, were obtained after space-flight mutation. With respect to the sand spores and slant spores, the mutation ratios were up to 67.6% ...
环丙沙星合成的新方法
ciprofloxacin synthesis quinolone
2009/3/10
A new synthetic method of ciprofloxacin is started with 2,4-dichloro-5-fluoroacetophenone, via oxaly lation, ethoxymethylenation, amination, cyclization, hydrolysis, decarbonylation and piperazinati...
一水盐酸环丙沙星初级成核机理的研究
ciprofloxacin hydrochloride monohydrate induction period primary nucleation
2009/2/24
A general expression for the relationship between induction period and supersaturation was developed based on polynuclear approach. Different mechanism of primary nucleation in solution can be illus...
固相萃取在兽药残留分析中的应用
固相萃取 兽药 残留分析
2008/12/30
近年来固相萃取技术在样品前处理中应用越来越广泛,文章根据固相萃取的不同分离模式,综述固相萃取在兽药残留中的应用,并总结不同性质目标化合物选择固相萃取的原则。
100、200、300升单轴型双锥回转真空干燥器的研制和在药品及无菌粉生产上应用的研究
干燥机 真空干燥机
2008/12/16
单轴型回转式双锥真空干燥器,是在双轴回转式真空干燥器(传统型式)的基础上,进一步开发研制的机型。在这项研究中成功地解决了干燥器中进、出热水、真空三种流体通过同一支承轴并达到密封要求以及支承轴与器身的合理连接机构等问题。这种单轴支承的结构,有可能使干燥器身单独进入洁净室,提高了干燥器对高洁净 环境的适应。本系列机组为适应若干规模的生产,干燥器容积设有100、200、300升三种,轴的支承结构、传动系...
10克药用铝质涂层软管的研制
铝质涂层 软管塑料喷涂 药用软管
2008/12/16
铝质涂层软管在国外已广泛应用于药膏包装,我国还没有一家厂能够生产药膏铝质软管,仍采用铅锡管,不仅锡用量大,而且不耐腐蚀。研制药膏铝质软管能节省锡材料,使药膏在保存期间更好地保证质量,消除铅锡管烂管现象。本课题研究内容包括三部分:铝质涂层软管生产工艺摸索、涂料的试制以及喷涂设备的试制。通过研究,改造生产药用规格软管的设备设计,制造半联动喷涂生产线;试制药用内层涂料即环氧酚醛清漆SO-Ⅰ和环氧胺基清漆...