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自噬是细胞自身调节维持稳态的重要过程,对机体具有重要的生理及病理学作用,是当今生命科学领域的研究热点之一. 随着纳米技术在生物医药领域日益广泛的应用,纳米颗粒诱导的自噬效应也引起了研究人员的关注,成为纳米毒理和纳米医药研究领域中一个新的研究方向. 本文扼要介绍了细胞自噬的基本情况,包括自噬的种类、诱导因素、自噬的调节和参与基因以及自噬在生命科学中的重要意义. 按照纳米颗粒的种类,重点阐述了纳米颗粒...
人工老化方法获得的不同生活力大豆种子为材料,采用3次多项式回归方法拟合其在20 ℃时无光照条件下的萌发进程,并对萌发进程曲线进行求导,从而建立了实时萌发速率曲线.对不同生活力大豆种子所拟合的2种曲线所包含的萌发起点、转折点、萌发速率顶点和对称轴等参数进行了分析,并与传统生活力评价进行比较,采用多项式回归方法评价种子生活力所含有用信息多,对评价种子生活力的下降更加灵敏和精确.
A grating-based biosensor via phase detection is stated. The resolution will be 10-7 RIU in the state-of-the-art today. The workspace can be shifted in a large range while the sensor resolution can re...
在热传导分析中,当热流与温度梯度存在时间延迟时,需采用非傅立叶热传导模型进行分析。生物组织具有较强的热松弛时间系数,承受激光、微波及烧烫等作用时,其呈现出较强的非傅立叶行为。本文对脉冲热源作用下生物组织的非傅立叶热传导进行研究,针对强脉冲引起的温度场在空间域的高梯度变化、波阵面的间断行为以及通用传统时域数值方法会带来虚假数值振荡的特点,提出采用所发展的时域间断Galerkin有限元法(DGFEM)...
采用自适应浸没边界方法,数值模拟了两条并列仿生鱼在不同间距下的同相位和反相位自主游动。通过与相同游动参数下单条仿生鱼自主游动的比较,可以得到结论:(1)并列自主游动的速度小于单条鱼游动的速度,并且随着间距减小而减小。相同间距下,反相位并列游动时的速度大于同相位;(2)并列游动时的阻力均大于单条鱼,且随着间距减小而增大;(3)反相位游动时功率消耗随间距减小而增大,但同相位游动则相反;(4)当间距大于...
Algal swimming is often biased by environmental cues, e.g. gravitational and viscous torques drive cells towards downwelling fluid (gyrotaxis). In view of biotechnological applications, it is importan...
We present a statistical mechanics analysis of the finite-size elasticity of biopolymers, consisting of domains which can exhibit transitions between more than one stable state at large applied force....
We investigate the full functional form of the first passage time density (FPTD) of a tracer particle in a single-file diffusion (SFD) system whose population is: (i) homogeneous, i.e., all particles ...
Recent experiments have illuminated a remarkable growth mechanism of rod-shaped bacteria: proteins associated with cell wall extension move at constant velocity in circles oriented approximately along...
Is there a functional role for quantum mechanics or coherent quantum effects in biological processes? While this question is as old as quantum theory, only recently have measurements on biological sys...
There is much current interest in modelling suspensions of algae and other micro-organisms for biotechnological exploitation, and many bioreactors are of tubular design. Using generalized Taylor dispe...
Wavelet transform of polarized fluorescence spectra of human breast tissues is found to localize spectral features that can reliably differentiate normal and malignant tissue types. The intensity diff...
Individual movements of a rod-like self-propelled particle on a flat substrate are quantified. Biological systems that fit into this description may be the Gram-negative delta-proteobacterium Myxococc...
The recently proposed close-packed motif for collagen is investigated using first principles semi-empirical wave function theory and Kohn-Sham density functional theory. Under these refinements the cl...
Mining gene expression profiles has proven valuable for identifying metagenes, defined as linear combinations of individual genes, serving as surrogates of biological phenotypes. Typically, such metag...

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