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Binding of Retinoids to ß-Lactoglobulin Isolated by Bioselective Adsorption
ß beta -lactoglobulin retinoid binding bio-selective adsorption whey protein isolate
2008/3/27
Binding of the retinoids, all-trans-retinol, all-trans-retinal, all-trans-retinyl acetate, and all-trans-retinoic acid, to ß-lactoglobulin (LG) (96% purity) that had been prepared by bioselectiv...
视黄类受体与视黄酸致畸作用关系Relations between the Retinoic Acid Acceptor and Teratogenesis of Retinoids
视黄类受体 视黄酸 致畸作用
2008/1/8
摘要
视黄酸(维甲酸)可引起包括人在内的多种动物胚胎畸形,其生物活性是由一系列视黄酸受体及其配体介导的。其中视黄类受体RAR起主要作用,RAR的配体为强致畸物,相对致畸活性由强至弱依次为配体α、配体β和配体γ。视黄酸受体RXR的配体无致畸活性,但是可加强RAR激动剂的某些致畸郊应。视黄酸受体还可通过其它基因的表达而影响胚胎发育。对视黄类受体基因突变和不同视黄类受体及其配体与致畸作用的关系,以及此...