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Synthetic modifications of abietane diterpene acids to potent antimicrobial agents
Dihydroquinopimaric acid maleopimaric acid antimicrobial activity antitubercular activity M tuberculosis H(37)Rv antifungal activity docking studies
2023/12/4
Among abietane type semisynthetic diterpenoids, a series of quinopimaric and maleopimaric acid derivatives modified at the carboxyl and carbonyl groups, and in ring E were synthesised to obtain new co...
Design, synthesis and biological evaluation of dehydroabietic acid derivative as potent vasodilatory agents
Dehydroabietic acid Vasodilation Inflammation Endothelial nitric oxide synthasec GMP
2023/11/30
Using dehydroabietic acid as the lead compound for structural modification, 25 dehydroabietic acid derivatives were synthesized. Among them, compound D1 not only showed the strongest relaxation effect...
Inhibition of SARS-CoV-2 (Previously 2019-nCoV) Infection by a Highly Potent Pan-Coronavirus Fusion Inhibitor Targeting Its Spike Protein That Harbors a High Capacity to Mediate Membrane Fusion
Inhibition SARS-CoV-2 Pan-Coronavirus Fusion Inhibitor Targeting High Capacity Mediate Membrane Fusion
2020/6/12
The recent outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection in Wuhan, China has posed a serious threat to global public health. To develop specific anti-coronavirus therapeuti...
Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody
2019-nCoV SARS-CoV ACE2 monoclonal antibody RBD
2020/6/12
The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 11,900 laboratory-confirmed human infections, including 259 deaths, posing a serious threat to human health. Currently, how...
One of the most potent toxins known acts by welding the two strands of the famous double helix together in a unique fashion which foils the standard repair mechanisms cells use to protect their DNA.A ...
Micron-sized hydrogel cubes show highly efficient delivery of a potent anti-cancer drug
Micron-sized hydrogel cubes highly efficient delivery anti-cancer drug
2017/7/24
Many potent anti-cancer drugs have major drawbacks — they fail to mix with water, which means they will have a limited solubility in blood, and they lack selectivity to cancer cells.Researchers at the...
Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/– mast cells
neurofibromin Schwann cells mast cells
2014/12/12
The NF1 tumor suppressor gene encodes a GTPase-activating protein called neurofibromin that negatively regulates Ras signaling. Mutations in NF1 cause neurofibromatosis type 1 (NF1). The development o...
IMT504: A New and Potent Adjuvant for Rabies Vaccines Permitting Significant Dose Sparing
IMT504 Adjuvant Rabies Vaccine Human Animal
2013/2/20
Background: Rabies virus infection causes encephalitis, which is almost always fatal. Vaccination can be extremely effective at preventing disease but is prohibitively costly. Vaccine formulations all...
Delivering a potent cancer drug with nanoparticles can lessen side effects（图）
a potent cancer drug nanoparticles side effects
2011/1/21
Researchers at MIT and Brigham and Women’s Hospital have shown that they can deliver the cancer drug cisplatin much more effectively and safely in a form that has been encapsulated in a nanoparticle t...
The aim of this paper is to offer an algebraic definition of infinite determinants of finite potent endomorphisms. This allows to construct a central extension of groups that can be interpreted as a ...
on bi—closed subbands of a band and free idem potent sem irings
semigroup idempotent semiring band bi—closed subband
2009/10/29
The bi—closed subbands of a band are introduced and its som e properties and characterizations are given．By using these results，the free object in the variety of idempotent semiringswhose additive red...
Sesamin,a Sesame Lignan,as a Potent Serum Lipid-Lowering Food Component
sesame fatty acid oxidation fatty acid synthesis lipoprotein production rat
2009/9/10
Effect of sesamin, a sesame lignan, on the hepatic fatty acid metabolism was examined in the rat. Increase of the dietary level of sesamin progressively increased the mitochondrial and peroxisomal fat...
Curcumin - A Potent Inhibitor of Galectin-3 Expression
galectin-3 curcumin UV light alkylating agent MNNG
2009/3/20
The expression of galectin-3, a β- galactoside binding lectin, was found to be affected by different kinds of stressors, and is strongly modified in numerous physiological and pathophysiological condi...
Lack of correlation between fertility and sperm numbers in male rats treated with histrelin, a potent LHRH agonist
correlation fertility sperm numbers male rats histrelin potent LHRH agonist
2009/2/23
Adult male rats were treated daily for up to 8 weeks with histrelin, [(ImBzl)-D-His6, Pro9-NEt]LHRH, to study the antifertility effects of this LHRH agonist. Although serum testosterone concentratio...
Dose-response studies on male reproductive parameters in dogs with nafarelin acetate, a potent LHRH agonist
LHRH agonist nafarelin acetate EDNal(2)6JLHRH spermatogenesis prostate male dogs
2009/2/20
Adult male beagle dogs were administered daily subcutaneous injections of either 0.5 or 2.0 micrograms/kg of a potent LHRH agonist, nafarelin acetate, for 44 days. Although there was a rise in the c...