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In response to glucose, pancreatic islet beta cells secrete insulin in a biphasic manner, and both phases are diminished in type 2 diabetes. In beta cells, cortical F-actin beneath the plasma membrane...
Modeling of the gap junction of pancreatic β-cells and the robustness of insulin secretion
pancreatic β-cells gap junctions synchronization robustness
2010/12/2
Pancreatic β-cells are interconnected by gap junctions, which allow small molecules to pass from cell to cell. In spite of the importance of the gap junctions in cellular communication, modeling studi...
Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion
Exoc3l protein exocyst subunit Sec6 insulin secretion
2009/3/2
The exocyst is an octameric complex involved in docking or tethering of secretory vesicles to fusion sites of the plasma membrane. Sec6 is the core subunit of the exocyst complex. Here we identify an ...
Many studies in the medical literature have indicated that the consumption of chili-containing meals increases energy expenditure and fat oxidation. Moving toward this direction, a new study regarding...