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Gossypol Broadly Inhibits Coronaviruses by Targeting RNA-Dependent RNA Polymerases
棉花 次生代谢物 棉酚 抑制冠状病毒
2024/4/16
研究团队以SARS-CoV-2为实验模型，采用计算机高通量筛选、酶学验证、抗病毒实验和冷冻电镜表征等多学科交叉的方式，从棉花中筛选到一种重要的次生代谢物——棉酚，发现棉酚能够广谱抑制冠状病毒。研究结果开辟了多学科交叉和多元化利用新方向，对促进棉花天然产物的研究和利用、拓宽棉花副产品的价值链具有重要意义。
Modifying Gossypol in Cotton（Gossypium hirsutum L）：A Cost Effective Method
Modifying Gossypol Cotton
2009/4/30
Cotton (Gossypium hirsutum L.) and related species all contain gossypol, a polyphenolic compound that is an integral part of the cotton plant’s self-defense system against insect pests and possibly so...
Gossypol-induced Differentiation in Human Leukemia HL-60 Cells
gossypol differentiation leukemia drug effects
2009/4/20
The main treatment of leukemia is traditional radiochemotherapy, which is associated with serious side effects. In the past twenty years, differentiation was found as an important effective measure to...
Incorporation of gossypol and formation of its protein conjugates in mouse transformed Sertoli（TM4）cells
protein conjugates mouse transformed Sertoli（TM4）cells
2009/2/23
Mitochondria of both mouse transformed Sertoli (TM4) cells and primary-cultured rat and mouse Sertoli cells were shown to be preferentially affected by gossypol (Tanphaichitr et al, 1984). To invest...
The correlation between the gossypol contents in blood plasma, rete testis fluid, and cauda epididymal fluid following chronic treatment with gossypol in rats
gossypol contents blood plasma rete testis fluid cauda epididymal fluid chronic treatment with gossypol in rats
2009/2/23
Concentrations of gossypol in blood plasma, rete testis fluid, and fluid from the caudia epididymidis were measured simultaneously by high performance liquid chromatography in rats treated with goss...
Differential effects of（+）and（-）gossypol enantiomers on mitochondrial function and proliferation of cultured TM4 cells
Gossypol isomer TM4 cells mitochondria
2009/2/23
The in vitro effects of (+) and (-)gossypol enantiomers on the mitochondrial functions of mouse transformed Sertoli, TM4 cells were investigated by monitoring mitochondrial rhodamine 123 accumulat...
Kinetic characterization of the inhibition of purified cynomolgus monkey lactate dehydrogenase isozymes by gossypol
Kinetic characterization purified cynomolgus monkey dehydrogenase isozymes gossypol
2009/2/23
This report describes the results of the first step in a sequence of experiments designed to test the hypothesis that the sperm-specific isozyme of lactate dehydrogenase (LDH-C4), is a site of actio...
Morphologic and endocrine changes in the reproductive organs in rats implanted with gossypol acetate pellet in the testis
Morphologic and endocrine changes reproductive organs rats implanted gossypol acetate pellet
2009/2/23
Gossypol acetate pellets in concentrations ranging from 0.5, 1.0, 5.0, 10.0, to 20.0 mg were implanted in the testis of rats for a period up to 7 weeks. The implant was made in one testis only. In...
Sertoli cell junctional complexes in gossypol-treated neonatal and adult guinea pigs
Sertoli cell gossypol-treated neonatal adult guinea pigs
2009/2/23
The effect of gossypol, an experimental male contraceptive agent, on the development and maintenance of the blood-testis barrier was determined by feeding gossypol daily to prepubertal and adult gui...
Racemic gossypol is an effective male antifertility agent in several mammalian species. However, (+)-gossypol is not an effective male antifertility agent in the rat or the hamster. Previous studies...
Effect of gossypol acetate on guinea pig epididymal spermatozoa in vivo and their susceptibility to capacitation in vitro
gossypol sperm motility sperm maturation cytoplasmic droplet capacitation acrosome reaction
2009/2/20
To determine the effects of gossypol acetate on guinea pig epididymal and vas deferens sperm maturity and in vivo susceptibility to in vitro capacitation and the acrosome reaction, we examined sperm...
Recovery of normal testicular ultrastructure and sperm motility after cessation of gossypol treatment in rats
normal testicular ultrastructure sperm motility gossypol treatment rats
2009/2/20
This study evaluates the reversibility of the effects of gossypol on testicular ultrastructure and the motility of epididymal spermatozoa. Adult male rats were treated 6 days weekly with the vehic...
Specific inhibition of the testicular mitochondrial respiratory chain in vitro by gossypol
Specific inhibition testicular mitochondrial respiratory chain gossypol
2009/2/20
Optically inactive gossypol is an effective male antifertility agent in several mammalian species, while optically active (+)-gossypol has no antifertility effect in the rat and hamster. Recently, i...
Effects of gossypol on rat Sertoli and Leydig cells in primary culture and established cell lines
rat Sertoli Leydig cells established cell lines
2009/2/19
In order to evaluate the direct effect of gossypol on testicular cells, we used primary cultures of rat Leydig and Sertoli cells. No alteration in Leydig cell survival, morphology, or testosterone...
Effect of gossypol on testicular testosterone production in vitro
gossypol testicular testosterone production
2009/2/19
Testicular minces were utilized to study the effect of gossypol on testosterone production. Testosterone production was assessed in both control nd gossypol treated groups after 0 to 4 hours incubat...