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Every day, billions of red blood cells pass through the spleen, an organ that is responsible for filtering out old or damaged blood cells. This task is made more difficult when the blood cells are mis...
New gene-editing technique shows promise against sickle cell disease（图）
镰状细胞性贫血 基因编辑技术 一次性治疗
2023/6/21
Ateam of researchers led by scientists from Harvard and the Broad Institute used a new gene-editing technique to successfully treat sickle cell disease in mice. This advancement could one day lead to ...
Gene editing study reveals possible 'Achilles heel' of sickle cell disease
Gene editing study Achilles heel sickle cell disease
2015/9/25
Researchers from Dana-Farber/Boston Children's Cancer and Blood Disorders Center have found that changes to a small stretch of DNA may circumvent the genetic defect behind sickle cell d...
Nitric Oxide and Trace Metals in Relation to Haemoglobin F Concentration in Nigerian Sickle Cell Disease Patients
Sickle cell disease trace metals haemoglobin F oxidants
2010/2/24
Sickle cell disease (SCD) is an inherited haemoglobin (Hb) disorder associated with vaso-occlusive events, oxidative stress, high energy demand, and endothelial dysfunction. The endothelium plays a ce...
Humoral immunity and haemoglobin F (HbF) status in steady state adult Nigerian sickle cell disease patients with asymptomatic malaria
Sickle cell disease malaria parasitaemia immunoglobulins inflammation haemolysis
2010/1/11
Aim: Nigeria, where malaria is prevalent, has the largest sickle cell gene pool in the world. To this end, there is a need for increased understanding of the pathophysiology of HbSS patients in a mala...
A Longitudinal Examination Predicting Emergency Room Use in Children with Sickle Cell Disease and Their Caregivers
emergency room utilization perceptions of disease sickle cell disease
2008/3/25
Objective To examine in a longitudinal investigation perceptions of disease severity among children and adolescents with sickle cell disease (SCD) and their caregivers and to determine whether percept...
Brief Report: Daily Mood as a Mediator or Moderator of the Pain–Sleep Relationship in Children with Sickle Cell Disease
diary mood pain sickle cell disease sleep
2009/12/21
Objective To investigate mood as a mediator or moderator of the pain-sleep relationship in children with sickle cell disease (SCD). Method Children with SCD (n = 20; aged 8–12 years) completed daily d...
Body composition in children with sickle cell disease
Sickle cell disease growth nutritional status body composition children African Americans
2016/12/19
Background: Impaired growth, poor nutritional status, and delayed skeletal and sexual maturation are common in children with sickle cell disease (SCD), yet the nature of associated body-compositi...
Energy intake and resting metabolic rate in preschool Jamaican children with homozygous sickle cell disease
Energy intake resting metabolic rate sickle cell disease children Jamaica weighed food intake
2016/12/17
Background: A relative energy deficiency consequent to a high resting metabolic rate (RMR) may contribute to growth impairment in persons with homozygous (SS genotype) sickle cell disease (S...
Effect of zinc supplementation on growth and body composition in children with sickle cell disease
Sickle cell disease zinc supplementation growth body composition children
2016/12/17
Background: Poor growth and delayed maturation in children with sickle cell disease (SCD) may be due, in part, to mild zinc deficiency.Objective: The objective was to determine the effects o...