搜索结果: 1-15 共查到“LHRH”相关记录32条 . 查询时间(0.186 秒)
LHRH-A对尼罗罗非鱼生长及生长轴相关基因表达的影响
尼罗罗非鱼 促黄体素释放激素类似物 生长 基因表达
2013/10/23
促性腺激素释放激素(GnRH)的主要作用是刺激脑垂体促性激素(GtH)的释放,亦可促进鱼类生长激素(GH)的释放。促黄体素释放激素类似物(LHRH-A)是哺乳类GnRH的类似物,为了分析LHRH-A对尼罗罗非鱼生长调节的作用,设计了长期和短期2个实验,采用腹腔注射(剂量0.1μg/g体重)方法,分析LHRH-A对尼罗罗非鱼绝对生长率、特定生长率、肝体系数和肥满度的影响,并应用荧光实时定量PCR方法...
长效LHRH拮抗剂的设计、合成和生物活性
LHRH拮抗剂 长效肽 睾酮
2009/11/13
根据抗蛋白酶降解的长效肽设计思想, 合成了一系列新型结构的LHRH拮抗剂类似物. 体内生物活性评价结果表明, 所设计的多肽具有比母体肽和阳性对照更长的体内抑制睾酮作用时间和较低的最低有效剂量, 证实了该设计思想的可行性, 并为开发长效LHRH拮抗剂药物提供了新的候选化合物.
取75尾网箱养殖的2～3龄雌性赤点石斑鱼，分为3组(高、低剂量组和对照组)，各25尾。高剂量组埋植促黄体生成素释放激素类似物(LHRH-A)缓释剂，剂量为300 μg/kg体重，低剂量组为100 μg/kg体重，对照组埋植不含LHRH-A的药丸。分别在实验开始和埋植药丸后0、10、20、30、40天抽血，用放射免疫测定血清类固醇激素(E2、T)；解剖鱼体测定相关指标，计算性腺成熟系数；取性腺和肝脏...
Mechanism of LHRH-stimulated steroidogenesis in rat Leydig cells：lipoxygenase products of arachidonic acid may not be involved
LHRH-stimulated steroidogenesis rat Leydig cells lipoxygenase products arachidonic acid
2009/2/23
Luteinizing hormone releasing hormone agonist, [(imBzl)-DHis6,Pro9,NEt]-LHRH (LHRH-A), caused a two to threefold increase in in vitro testosterone (T) secretion by rat Leydig cells. This LHRH-A-indu...
Pituitary response to LHRH during chronic renal insufficiency in the male rat
Pituitary LHRH chronic renal insufficiency male rat
2009/2/23
Chronic renal insufficiency was induced in young adult male rats by a 2-step 5/6 nephrectomy. Four weeks after surgery the rats were anesthetized with ketamine and injected with saline or 1, 5, 10...
Reversal of testicular function after prolonged suppression with an LHRH agonist in rhesus monkeys
testicular function prolonged suppression LHRH agonist rhesus monkeys
2009/2/23
Using subcutaneously implanted osmotic pumps, four male rhesus monkeys were continuously infused for 18 months with 100 micrograms/day of [(imBzl)-D-His6-Pro9-NEt]-LHRH (LHRH-A), a potent agonist of...
Heterogeneity of sperm density profiles following 16-week therapy with continuous infusion of high-dose LHRH analog plus testosterone
sperm density profiles 16-week therapy high-dose LHRH testosterone
2009/2/23
LHRH agonist analogs have been investigated as potential male contraceptives. It has been shown that the LHRH agonistic analog [D-Trp6,Pro9-NEt] LHRH (LHRHA) given to men in single doses up to 500 m...
Lack of correlation between fertility and sperm numbers in male rats treated with histrelin, a potent LHRH agonist
correlation fertility sperm numbers male rats histrelin potent LHRH agonist
2009/2/23
Adult male rats were treated daily for up to 8 weeks with histrelin, [(ImBzl)-D-His6, Pro9-NEt]LHRH, to study the antifertility effects of this LHRH agonist. Although serum testosterone concentratio...
Dose-response studies on male reproductive parameters in dogs with nafarelin acetate, a potent LHRH agonist
LHRH agonist nafarelin acetate EDNal(2)6JLHRH spermatogenesis prostate male dogs
2009/2/20
Adult male beagle dogs were administered daily subcutaneous injections of either 0.5 or 2.0 micrograms/kg of a potent LHRH agonist, nafarelin acetate, for 44 days. Although there was a rise in the c...
Recovery of gonadal functions in the adult male rat following cessation of five-month daily treatment with an LHRH agonist
LHRH agonist testicular steroidogenesis ventral prostate seminal vesicles spermatogenesis
2009/2/20
This study describes the recovery of various parameters of the pituitary-gonadal axis following five months of daily treatment of adult male rats with a potent LHRH (luteinizing hormone-releasing ...
Heterogeneity of sperm density profiles following 20-week therapy with high-dose LHRH analog plus testosterone
LHRH analog sperm density heterogeneous response
2009/2/20
Eight normal male volunteers received an LHRH analog, 100 to 500 micrograms daily, for 20 weeks. Testosterone enanthate, 100 mg, was given by injection every second week. Sperm density fell to 5.5 X...
Effects of an LHRH agonist analog upon sexual function in male dogs. Suppression, reversibility, and effect of testosterone replacement
LHRH agonists D-Na!(2)6-LHRH spermatogenesis
2009/2/20
Male beagle dogs were injected once daily with 10 micrograms/kg of [6-D-(2-naphthyl)alanine]-LHRH (D-Nal(2)6-LHRH), a potent LHRH agonist, for periods up to 42 days, with recovery periods up to 172 ...
Combined treatment with an LHRH agonist and testosterone in man. Reversible oligozoospermia without impotence
LHRH (GnRH) testosterone spermatogenesis
2009/2/19
We have previously shown that LHRH agonist [D-Trp6,Pro9-NEt]LHRH (LHRHA) results in reversible oligozoospermia when given to normal subjects for up to ten weeks. A fall in plasma testosterone was ac...
Inability of continuous long-term administration of D-Nal（2）6-LHRH to abolish fertility in male rats
D-Nal(2)6-LHRH fertility male rats
2009/2/19
A highly potent agonist of LHRH, [6-D-(2-naphthyl)-alanine]-LHRH, was administered chronically for 12 weeks to adult male rats by repetitive implantation of pellets, and its effects upon mating, fer...
Animal model of isolated gonadotropin deficiency. II. Morphologic responses to LHRH immunoneutralization
hypogonadotropic-hypogonadism LHRH dog immunohypophysectomy testis prostate excurrent
2009/2/19
Morphologic changes in the male reproductive system of mongrel dogs immunized against LHRH were quantitated using linear measurements and morphometric techniques at the light-microscopic level. Two ...