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2017细胞命运和疾病基因组结构戈登学术会议（The 2017 Gordon Research Conference on Genome Architecture in Cell Fate&Disease ）
2017 细胞命运和疾病基因组结构戈登 学术会议
2017/2/14
Accumulating evidence suggest that genomes are organized non-randomly into complex 3D configurations that vary according to cell type, stage of development, differentiation and disease status. The pri...
REGULATION OF CHOP TRANSLATION IN RESPONSE TO eIF2 PHOSPHORYLATION AND ITS ROLE IN CELL FATE
Stress (Physiology) Messenger RNA Apoptosis
2015/5/25
In response to different environmental stresses, phosphorylation of eukaryotic initiation factor-2 (eIF2) rapidly reduces protein synthesis, which lowers energy expenditure and facilitates reprogrammi...
The integrated stress response directs cell fate decisions in response to perturbations in protein homeostasis
diabetes cancer
2015/5/25
Disruptions of the endoplasmic reticulum (ER) cause perturbations in protein folding and result in a cellular condition known as ER stress. ER stress and the accumulation of unfolded protein activate ...
Bayesian inference and model choice in a hidden stochastic two-compartment model of hematopoietic stem cell fate decisions
Stochastic two-compartment model hidden Markov models reversible jump MCMC hematopoiesis stem cell asymmetric division
2010/11/8
Despite rapid advances in experimental cell biology, the in vivo behavior of hematopoietic stem cells (HSC) cannot be directly ob-served and measured. Previously we modeled feline hematopoiesis using ...