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Six rats were trained to make an operant response to receive brief trains of electrical current to the lateral hypothalamus (self-stimulation). All animals were then randomly exposed to pressures of 4...
Failure of certain circulating substances to penetrate specific organs led to the concept of blood-organ barriers. Such barriers can be altered by various physical or chemical means. This report conce...
An investigation was undertaken to determine whether permanent damage to the central nervous system (CNS) is associated with transient decompression sickness in the goat. Twelve goats were compressed ...
Alteration of the blood-brain barrier (BBB) by dysbaric exposure may have relevance in several areas of hyperbaric medicine. Drugs administered to persons exposed to dysbaric conditions, e.g., divers,...
Brain and rectal temperatures were measured in guinea pigs exposed to helium-oxygen environments at pressures as high as 50 bars. Very high correlations (r = .856, P less than 0.001) between the two v...
A study has been made of changes in permeability of the blood-brain barrier (BBB) to drugs following exposure to compression-decompression. Fifty-five rats were exposed to 6.1 b (abs) air for 90 min a...
Electrocardiogram (ECG), electrocorticogram (ECoG), and respiratory rate (RR) were monitored in awake, unrestrained rats during continuous exposure to 1, 3, and 5 ATA O2 until death. The RR showed a c...
The effect of 1, 2, and 5 mg/kg propranolol on the neuroelectrophysiological manifestations of CNS oxygen toxicity was studied in conscious rats. Cortical electrodes for electrocorticographic (ECoG) r...
Excitatory amino acid antagonists have been shown to protect against the hyperexcitability associated with exposure to high pressure. This suggests that these excitatory neurotransmitter substances ma...
The effects of 71 ATA pressure on the turnover of serotonin (5-HT), noradrenaline (NA), and dopamine (DA) were studied. High pressure increased the concentration of the 5-HT metabolite 5-hydroxyindole...
The pattern of neurotransmitter release in the rat caudate and hypothalamus was studied following exposure to pressure in combination with various gas mixtures. The caudate was selected for its contro...
Decompression sickness affecting the nervous system is still a serious problem in diving, but the mechanisms involved are in dispute. Although microbubbles can be detected in the pulmonary artery on d...
It is known that inert gas narcosis slows both reaction time (RT) and the event-related brain potential P300 in a correlated and dose-dependent manner. On the assumption that P300 reflects the time to...
We investigated the effects of 24-h oxygen therapy on focal cerebral ischemia in rats. Under halothane anesthesia, a 3-0 nylon thread was introduced into the neck internal carotid artery to occlude th...
The role of brain computerized tomography (CT) imaging in predicting clinical outcome was investigated in patients receiving hyperbaric oxygen therapy for serious carbon monoxide (CO) poisoning. From ...

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