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Mechanism of tissue transglutaminase upregulation and its role in ovarian cancer metastasis
tissue transglutaminase TGF-beta ovarian cancer
2015/5/25
Ovarian cancer (OC) is a lethal disease due to metastasis and chemoresistance. Our laboratory previously reported that tissue transglutaminase (TG2) is overexpressed in OC and enhances OC peritoneal m...
siRNA-toting nanoparticles inhibit breast cancer metastasis
siRNA-toting nanoparticles inhibit breast cancer metastasis
2015/5/25
Researchers at Case Western Reserve University combined finely crafted nanoparticles with one of nature’s potent disrupters to prevent the spread of triple-negative breast cancer in mouse models.The h...
Intratumour heterogeneity in the progression to breast cancer metastasis
Intratumour heterogeneity breast cancer metastasis
2015/4/14
Unlike the great advances that have been made in reducing breast cancer mortality through the multidisciplinary treatment of primary disease, much less is understood about the natural history of metas...
Cancer progression is characterised by extensive metabolic reprogramming. Renewed enthusiasm in this field has been sparked in part by the realisation that metabolic pathways, oncogenes and tumour sup...
Tumour cells secrete small membrane vesicles (30-100nm) termed exosomes, that are derived from late endosomal compartments of cells. Exosomes are increasingly being recognised for their role in interc...
Disparate functions of myeloid-derived suppressor cells in cancer metastasis
Disparate functions cancer metastasis
2015/4/14
Myeloid-derived suppressor cells comprise a heterogeneous population of immature immune cells that expand during the course of cancer progression. These cells adopt an immunosuppressive phenotype that...
Cancer remains a major cause of mortality, chiefly through metastatic spread of tumour cells to distant organs via the blood vascular or lymphatic circulations. The latter system has been more recentl...