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A comparative analysis of cAMP-dependent protein kinase regulatory subunits in sea urchin and rat spermatozoa
spermatozoa azido photoprobes protein kinase nucleotides epididymis
2009/2/23
8-Azido cAMP photoaffinity labeling of cAMP-dependent protein kinase regulatory subunits (R1 = 49 K;R2 = 55K) was done on spermatozoa from species lacking, and species containing an epididymis. Sper...
The aging Leydig cell. VIII. Protein kinase activity
The aging Leydig cell Protein kinase activity
2009/2/19
The effects of aging on cyclic AMP (cAMP) dependent protein kinase activity of purified Leydig cells were evaluated. Purified Leydig cells from 20-day-, 40-day-, 60-day- and 30-month-old rats were...
Motility potential of macaque epididymal sperm: the role of protein phosphatase and glycogen synthase kinase-3 activities
Monkey spermatozoa enzymes caput caudal
2009/2/18
Human and monkey ejaculated sperm contain protein phosphatase-1 (PP1), PP1 inhibitor 2 (12), and glycogen synthase kinase-3 (GSK-3). Inhibition of ejaculated human sperm protein phosphatase (PP) a...
Protein kinase CK2 activities in human prostatic and seminal-vesicle secretions and seminal plasma
Prostate vasectomy normozoospermia oligozoospermia
2009/2/18
Human prostatic secretion and seminal plasma contain certain protein kinase activities. Protein kinases play important roles in regulating a vast variety of cellular functions. The objective of this...
Expression of cyclin-dependent kinase 5 and associated cyclins in Leydig and Sertoli cells of the testis
cyclin-dependent kinase 5 associated cyclins Leydig and Sertoli cells
2009/2/18
In this study, we examined the expression and subcellular localization of cyclin-dependent kinase 5 (Cdk5), cyclin D1, and cyclin E in Leydig and Sertoli cell lines that were cultured with 7.5, 1....
Cytoplasmic extrusion and the switch from creatine kinase B to M isoform are completed by the commencement of epididymal transport in human and stallion spermatozoa
Maturity and function men stallions fertility cytoplasmic
2009/2/17
Although in several species there is a relationship between epididymal sperm transport and fertility, in human in vitro fertilization (IVF), spermatozoa recovered from the caput epididymidis or ev...
Anti-proliferative effect of the kinase inhibitor K252a on human prostatic carcinoma cell lines
Anti-proliferative effect kinase inhibitor K252a human prostatic carcinoma cell lines
2009/2/16
Members of the K252 family of kinase inhibitors have been demonstrated to inhibit a number of neurotrophin-mediated cellular responses, and to preferentially inhibit the activity of neurotrophin recep...
Chloride efflux during the progesterone-initiated human sperm acrosome reaction is inhibited by lavendustin A, a tyrosine kinase inhibitor
GABAA receptor Cl- channel
2009/2/16
Previous studies showed that progesterone (P) can initiate the mammalian sperm acrosome reaction (AR) in vitro and that a sperm GABAA-like receptor/Cl- channel is involved in an essential Cl- effl...
Atrial natriuretic factor inhibits the phosphorylation of protein kinase C in plasma membrane preparations of cultured Leydig tumor cells
Atrial natriuretic factor protein kinase C Leydig tumor cells cGMP plasma membranes
2009/2/12
The peptide hormone atrial natriuretic factor (ANF) exerts its effect in a receptor-mediated fashion and the membrane-bound form of guanylate cyclase represents a biologically active ANF receptor;...
Correlation between the rate of lipid peroxidation and cellular maturity as measured by creatine kinase activity in human spermatozoa
Spermatogenesis sperm development oligospermia male fertility
2009/2/12
We have demonstrated previously that creatine kinase (CK) activity is a measure of cellular maturity and fertilizing potential in human spermatozoa. In the present work we have examined whether th...
Sperm creatine kinase activity in fertile and infertile oligospermic men
sperm (human) sperm CK sperm CK activity
2009/1/5
The authors examined the value of sperm creatine-kinase (CK) activity parameters to predict sperm fertilizing potential of oligospermic men. Two patient groups from our intrauterine insemination pro...
Protein kinase C increases 11beta-hydroxysteroid dehydrogenase oxidation and inhibits reduction in rat Leydig cells
Calcium calmodulin glucocorticoid action oxidoreductases
2008/12/30
Glucocorticoid hormone controls Leydig cell steroidogenic function through a receptor-mediated mechanism. The enzyme 11beta-hydroxysteroid dehydrogenase (11betaHSD) plays an important role in Leydig...
Androgen receptor regulation of G1 cyclin and cyclin-dependent kinase function in the CWR22 human prostate cancer xenograft
Androgen receptor regulation G1 cyclin cyclin-dependent kinase CWR22 huma prostate cancer
2008/12/29
Human prostate cancer is initially dependent on androgens for growth, and androgen-dependent cells undergo apoptosis after castration. However, a subset of androgen-responsive cells survives and event...
Effects of luteinizing hormone, follicle-stimulating hormone, and epidermal growth factor on expression and kinase activity of cyclin-dependent kinase 5 in Leydig TM3 and Sertoli TM4 cell lines
luteinizing hormone follicle-stimulating hormone growth factor kinase activity cyclin-dependent kinase 5
2008/12/25
We examined the effects of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and epidermal growth factor (EGF) on the expression and kinase activity of cyclin-dependent kinase 5 (Cdk5)...
Mice Lacking Raf Kinase Inhibitor Protein-1 (RKIP-1) Have Altered Sperm Capacitation and Reduced Reproduction Rates With a Normal Response to Testicular Injury
PEBP testis
2008/12/24
Raf kinase inhibitor protein-1 (RKIP-1) belongs to the phosphatidyl ethanolamine–binding family of proteins (PEBP), which are highly conserved throughout evolution and widely expressed in tissues...