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The Effects of Cyclic Adenine Nucleotides, Phosphodiesterase Inhibitors, and Cauda Epididymidal Fluid on the Motility of Rat Epididymal Spermatozoa
spermatozoa motility epididymal rat
2009/2/19
Experiments were performed to determine whether the rat epididymis secretes a "forward-motility" factor(s) similar to that found by others in the bovine epididymis. Lumen content of the rat caput ...
In Vitro Effect of Inhibin on Cyclic AMP-Phosphodiesterase Activity in Rat Testes
inhibin cyclic AMP-phosphodiesterase
2009/2/19
We have previously reported that incubation of testicular slices with inhibin in the presence of 6 x 10-8 M oFSH resulted in a dose-related reduction in accumulation of cyclic AMP due to a decreas...
Observations on Cyclic Nucleotides in Human Semen
semen cyclic AMP cyclic GMP adenylate cyclase fructose
2009/2/19
In agreement with earlier studies, we have found that the human seminal plasma yields considerably higher values for cyclic nucleotides when compared with spermatozoa. However, we have also show...
Interaction between Ca2+, cyclic 3',5' adenosine monophosphate, the superoxide anion, and tyrosine phosphorylation pathways in the regulation of human sperm capacitation
Calmodulin phosphatase kinase
2009/2/17
In order to fertilize the egg, spermatozoa must go through the capacitation process where they experience Ca2+ uptake, increases in cyclic 3',5' adenosine monophosphate (cAMP) concentrations, supe...
The cyclic GMP-specific phosphodiesterase inhibitor, sildenafil, stimulates human sperm motility and capacitation but not acrosome reaction
cyclic GMP-specific phosphodiesterase inhibitor sildenafil human sperm motility capacitation
2008/12/25
Capacitation is the series of transformations that spermatozoa undergo in the female genital tract in order to bind to the zona pellucida, initiate the acrosome reaction, and fertilize an egg. Cyc...
A Cyclic Adenosine 3',5'-Monophosphate Stimulates Phospholipase C1-Calcium Signaling via the Activation of Tyrosine Kinase in Boar Spermatozoa
Sperm cAMP SYK PLC calcium store
2008/12/23
The aim of this study was to reveal a downstream part of the intracellular signaling that is mediated by cyclic adenosine monophosphate (cAMP)-dependent tyrosine kinases, including spleen tyrosine (...
Impaired Sperm Function After Spinal Cord Injury in the Rat Is Associated With Altered Cyclic Adenosine Monophosphate Signaling
cAMP SYBR-14 JC-1
2008/12/23
Our previous observations of changes in the expression of cAMP-dependent genes and the cAMP-responsive element modulator (CREM) in rat testicular cells after spinal cord injury (SCI) implied abnor...
Stage- and Cell-Specific Expression of Soluble Guanylyl Cyclase Alpha and Beta Subunits, cGMP-Dependent Protein Kinase I Alpha and Beta, and Cyclic Nucleotide-Gated Channel Subunit 1 in the Rat Testis
Cyclic guanosine monophosphate sGC PKG-I CNG-1
2008/12/23
Several studies suggest that nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) modulate testicular function. In this study, we examined the expression of cGMP-dependent protein kinase ...
Viability and Protein Phosphorylation Patterns of Boar Spermatozoa Agglutinated by Treatment With a Cell-Permeable Cyclic Adenosine 3',5'-Monophosphate Analog
Serine/threonine phosphorylation tyrosine phosphorylation hyperactivation
2008/12/19
Boar spermatozoa become agglutinated with one another at the head when their intracellular cyclic adenosine 3',5'-monophosphate (cAMP)-signaling cascades are activated in the head. The aim of the ...
Involvement of Cytoplasmic Free Calcium in Boar Sperm: Head-to-Head Agglutination Induced by a Cell-Permeable Cyclic Adenosine Monophosphate Analog
Capacitation BAPTA thapsigargin fluo-3 Ca2+-ATPase
2008/12/18
When boar spermatozoa are incubated in a medium designed for in vitro fertilization, many of them become agglutinated at the acrosomes. We previously reported that bicarbonate and cyclic adenosine...