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Effect of MK-906, a specific 5 alpha-reductase inhibitor, on serum androgens and androgen conjugates in normal men
MK-906 5 alpha-reductase inhibitor serum androgens androgen conjugates normal men
2009/2/23
To determine the hormonal effects of MK-906, an orally active 5 alpha-reductase inhibitor, on serum androgens and androgen conjugates, 12 healthy men were given 10, 20, 50, and 100 mg MK-906 2 weeks a...
Interactions of androgens and prolactin in the seminal vesicles of mature bonnet monkeys, Macaca radiata. I. Nucleic acids and phosphatases
androgens prolactin seminal vesicles mature bonnet monkeys
2009/2/23
The effects of prolactin (PRL), bromocriptine, testosterone propionate (TP), dihydrotestosterone (DHT), and the combinations of these androgens with PRL or bromocriptine on nucleic acids (RNA and DN...
Androgens in various fluid compartments of the rat testis and epididymis after hypophysectomy and gonadotropin supplementation
androgens testis epididymis hypophysectomy rat
2009/2/23
Hypophysectomized male rats were administered LH or LH + FSH for 14 days and subjected to in vivo micropuncture collection of reproductive tract fluids to determine if FSH alters the compartmentaliz...
Administration of constant low doses of androgens to steers by silastic implant. Suppression of gonadotropins and peripheral conversion of androgens
androgen implants steers gonadotropins peripheral metabolism of androgens
2009/2/20
Yearling Hereford calves approximately 300 kg in weight were castrated and assigned to one of six treatment groups receiving subcutaneous implants (3 implants, 0.5 cm diameter by 10 cm length, 10% s...
Effects of Dibromochloropropane Upon Diurnal Variations of Gonadotropins and Androgens
dibromochloropropane testis histology gonadotropins androgens diurnal variations
2009/2/18
The effects of exposure to dibromochloropropane (DBCP) for one to seven years on testicular physiology were evaluated in five men by measuring the circulating levels of FSH, LH, androstenedione, t...
Serum androgens：associations with prostate cancer risk and hair patterning
Prostatic neoplasms hormones testosterone baldness
2009/2/17
Cancer of the prostate is the leading cancer among American men, yet few risk factors have been established. Hair growth and development are influenced by androgens, and it has long been suspected...
Androgens modulate the alpha-adrenergic responsiveness of vascular smooth muscle in the corpus cavernosum
Penile erection testosterone adrenergic prazosin
2009/2/17
Rat penile erection is an androgen-dependent process with castration leading to a loss of potency. The present study was designed to determine if one of the mechanisms by which androgens maintain th...
Testosterone and spermatogenesis: evidence that androgens regulate cellular secretory mechanisms in stage VI-VIII seminiferous tubules from adult rats
Testosterone spermatogenesis androgens regulate cellular secretory mechanisms adult rats
2009/2/13
The aim of this study was to investigate the effect of testosterone manipulation on the quantitative synthesis and secretion of a number of specific proteins produced by seminiferous tubules (ST) ...
Appearance of alpha-smooth muscle actin in peritubular cells of monkey testes is induced by androgens, modulated by follicle-stimulating hormone, and maintained after hormonal withdrawal
alpha-smooth muscle actin peritubular cells androgens follicle-stimulating hormone
2009/2/12
This study analyzed the hormonal requirements necessary for the development of primate testicular peritubular cells. Alpha-smooth muscle actin, as a specific differentiation marker for peritubular c...
Normal and abnormal development of the male urogenital tract. Role of androgens, mesenchymal-epithelial interactions, and growth factors
urogenital development mesenchymal-epithelial interactions seminal vesicle prostate cancer keratinocyte growth fact
2009/2/11
Androgen-dependent male urogenital development occurs via mesenchymal-epithelial interactions in which mesenchyme induces epithelial morphogenesis, regulates epithelial proliferation, and evokes e...
Overview of enzyme inhibitors and anti-androgens in prostatic cancer
enzyme inhibitors anti-androgens prostatic cancer
2009/2/7
Surgical castration and estrogen therapy for prostate cancer were developed in 1941, and have been shown to improve both quality of life and survival. Little change in the therapeutics of prostate...
Metabolism of 5 alpha reduced androgens by various tissues of the male rat
metabolism androgens glucuronides
2009/2/6
Since an animal model for the study of peripheral androgen metabolism is needed, we studied the metabolism of 5 alpha-reduced androgens in various tissues of the rat. Labeled DHT and 3 alpha androst...
Regulation of caltrin mRNA expression by androgens in the murine prostate
caltrin mRNA androgens murine prostate
2008/12/26
Testicular androgens induce the proliferation and differentiation of prostatic epithelial cells by regulating the expression of androgen target genes. The use of subtractive hybridization to isolate...
Effects of long-term administration of androgens and estrogen on rhesus monkey prostate：possible induction of benign prostatic hyperplasia
long-term administration androgens estrogen rhesus monkey prostate
2008/12/25
Rhesus monkeys were used to investigate the role of androgenic steroids and estradiol in the induction of hyperplastic changes in stromal and glandular prostate tissues. Adult male rhesus monkeys ...
Biphasic Effect of Androgens on Prostate Cancer Cells and Its Correlation With Androgen Receptor Coactivator Dopa Decarboxylase
Neuroendocrine differentiation methyltoenolone cDNA microarray
2008/12/24
The aim of this study was to explore the mechanism underlying the dual effect of androgen on prostate cancer cells and further explore its correlation with dopa decarboxylase (DDC), an androgen r...