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Dynamin and PTP-PEST cooperatively regulate Pyk2 dephosphorylation in osteoclasts
signaling Tyrosine kinase Osteoclasts
2014/11/6
Bone loss is caused by the dysregulated activity of osteoclasts which degrade the extracellular bone matrix. The tyrosine kinase Pyk2 is highly expressed in osteoclasts, and mice lacking Pyk2 exhibit ...
Signaling via the Pyk2-Src-Cbl complex downstream of integrins contributes to the assembly, organization, and dynamics of podosomes, which are the transient adhesion complexes of highly motile cells s...
Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2W22;/W22; mice
podosome organization bone density osteoclast functions
2014/11/6
The protein tyrosine kinase Pyk2 is highly expressed in osteoclasts, where it is primarily localized in podosomes. Deletion of Pyk2 in mice leads to mild osteopetrosis due to impairment in osteoclast ...