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首次发现胚胎发育中眼睑闭合调控机制——华南理工大学医学院王键教授团队研究成果以封面文章发表在Science Signaling（图）
胚胎发育 中眼睑闭合 调控机制 王键 教授 研究成果 封面文章 Science Signaling
2018/11/7
近日，华南理工大学医学院王键教授带领的神经生物学团队在世界上首次发现胚胎发育中眼睑闭合的调控机制，相关成果以“Sphingosine 1-phosphate stimulates eyelid closure in the develop rat by stimulating EGFR signaling”为题，在Science Signaling以封面文章发表。在胚胎发育的过程中，眼睑需要闭合以...
2016冷泉港学术会议：代谢信号机制（Cold Spring Harbor conference on Mechanisms of Metabolic Signaling）
Genetics Genomes
2017/1/19
Metabolic regulation is at the intersection of many scientific fields, ranging from basic biochemistry and molecular biology to physiology, to the study of disease pathogenesis. Currently, a major cha...
2017疾病模式识别信号 Keystone Symposia（2017 Keystone Symposia on Pattern Recognition Signaling: From Innate Immunity to Inflammatory Disease）
PRR Signaling Inflammatory Disease
2017/1/13
The meeting will begin on Sunday, March 19 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 23 with a closing plenary sessio...
TRANSGENIC USE OF SMAD7 TO SUPPRESS TGFβ SIGNALING DURING MOUSE DEVELOPMENT
heart development doxycycline inducible
2015/5/25
Neural crest cells (NCC) are a multipotent population of cells that form at the dorsal region of neural tube, migrate and contribute to a vast array of embryonic structures, including the majority of ...
The effects of CaMKII signaling on neuronal viability
Calcium/calmodulin-dependent protein kinase II CaMKII Neuron Neurotransmitter Neurotoxicity
2015/5/21
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a critical modulator of synaptic function, plasticity, and learning and memory. In neurons and astrocytes, CaMKII regulates cellular excitabi...
Resolution of Inflammation Induces Osteoblast Function and Regulates the Wnt Signaling Pathway
inflammation osteoblast
2014/12/4
Objective Inflammation in the bone microenvironment stimulates osteoclast differentiation, resulting in uncoupling of resorption and formation. Mechanisms contributing to the inhibition of osteoblast ...
Nitric oxide acts through different signaling pathways in maturation of cumulus cell-enclosed mouse oocytes
Nitric oxide Sildenafil Oocytes maturation Signaling pathway
2009/12/16
Background: Nitric oxide (NO) have a dual action in mouse oocyte meiotic maturation which depends on its concentration, but the mechanisms by which it influences oocyte maturation has not been exactly...
Sho-seiryu-to Suppresses Histamine Signaling at the Transcriptional Level in TDI-Sensitized Nasal Allergy Model Rats
allergy gene expression histamine H1 receptors histamine signaling histidine decarboxylase Th2 cytokines
2010/11/16
SST significantly suppressed TDI-induced nasal allergy-like symptoms. TDI provocation showed a significant up-regulation of histamine H1 receptor (H1R) and histidine decarboxylase (HDC) gene expressio...
T cell signaling: Protein kinase Cθ, the immunological synapse and characterization of SLAT, a novel T helper 2-specific adapter protein
immune synapse protein kinase Cθ SLAT T cell receptor CD28 Th2
2010/11/24
Triggering of the antigen-specific T cell receptor (TCR) can lead to various functional outcomes, such as activation and proliferation, anergy or cell death. This differential signaling is mainly dete...
Effects of ultraviolet-inactivated herpes simplex virus type I on atopic dermatitis-like lesions in NC/Nga mice: Role of the suppressor of cytokine signaling in the skin
atopic dermatitis herpes simplex virus suppressor of cytokine signaling (SOCS) Th1 Th2
2010/11/22
Ultraviolet-inactivated HSV treatment would appear to induce a Th1 cellular response and downregulate that of the Th2 pathway in AD-like lesions of NC/Nga mice by bringing about a reduction of SOCS3 e...
β2-Adrenergic receptors: Structure, regulation and signaling by partial and full agonists
β2-adrenergic receptor selective agonist agonist-specific conformation constitutively active receptor
2010/11/22
It is believed that G-protein-coupled receptors are the most promising target proteins for drug research. The β2-adrenergic receptor has been analyzed extensively in terms of its structure, regulation...
Role of signaling lymphocytic activation molecule in T helper cell responses
allergy interferon-γ signaling lymphocytic activation molecule (CDw150) T cell activation Th2 responses
2010/11/29
Signaling lymphocytic activation molecule (SLAM; CDw150) is a 70 kDa glycoprotein. Signaling lymphocytic activation molecule is constitutively expressed on memory T cells, CD56+ T cells, a subset of T...